Publication Name	World Journal of Gastroenterology
Manuscript ID	18876
Country	France

Received	2015-04-28 12:36
Peer-Review Started	2015-05-06 07:46
To Make the First Decision	2015-08-25 16:02
Return for Revision	2015-08-26 09:38
Revised	2015-09-06 23:20
Second Decision	2015-10-12 16:31
Accepted by Journal Editor-in-Chief	2015-10-12 18:25
Accepted by Executive Editor-in-Chief	2015-10-20 09:14
Articles in Press	2015-10-20 09:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-13 11:31
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Gut microbiota imbalance and colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet and Mathilde Bonnet
Funding Agency and Grant Number	Funding Agency Grant Number Inserm and Université d’Auvergne UMR 1071 INRA USC-2018 "Conseil regional d’Auvergne" "Nuovo Soldati Foundation for Cancer Research" "Fondation pour la recherche médicale"
Corresponding Author	Mathilde Bonnet, PhD, M2iSH “Microbes, intestin, inflammation et Susceptibilité de l’Hôte” UMR 1071 Inserm/Université d’Auvergne USC INRA 2018, Centre Biomédical de Recherche et Valorisation, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France. mathilde.bonnet@udamail.fr
Key Words	Colorectal cancer; Gut microbiota; Dysbiosis; Cyclomodulin; Oxidative stress
Core Tip	The gut microbiota acts as a real organ and many changes in its composition have been reported in colorectal cancer. The pro-carcinogenic properties of bacteria are now better understood. In this review, we discuss possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on the dysbiosis-causing and pro-carcinogenic properties of bacteria, such as genotoxicity, inflammation, and oxidative stress. We lastly detail how microbiota modifications may represent novel prognosis markers and/or targets for innovative therapeutic strategies.
Publish Date	2016-01-06 16:13
Citation	Gagnière J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E, Bringer MA, Pezet D, Bonnet M. Gut microbiota imbalance and colorectal cancer. World J Gastroenterol 2016; 22(2): 501-518
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/501.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.501

Full Article (PDF)	WJG-22-501.pdf
Full Article (Word)	WJG-22-501.doc
Manuscript File	18876-Review.docx
Answering Reviewers	18876-Answering reviewers.pdf
Audio Core Tip	18876-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18876-Conflict-of-interest statement.pdf
Copyright License Agreement	18876-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18876-Language certificate.pdf
Peer-review Report	18876-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18876-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18876-Scientific misconduct check.pdf
Scientific Editor Work List	18876-Scientific editor work list.pdf