Publication Name	World Journal of Gastroenterology
Manuscript ID	18945
Country	South Korea

Received	2015-04-28 14:16
Peer-Review Started	2015-05-07 09:16
To Make the First Decision	2015-08-25 16:02
Return for Revision	2015-08-26 10:45
Revised	2015-09-08 20:02
Second Decision	2015-11-02 09:05
Accepted by Journal Editor-in-Chief	2015-11-04 08:40
Accepted by Company Editor-in-Chief	2015-11-13 17:20
Articles in Press	2015-11-13 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-22 15:46
Typeset the Manuscript	2015-12-30 16:16
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Changing strategies for target therapy in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Suk-young Lee and Sang Cheul Oh
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Trade, Industry and Energy 10041653 (The Technology Innovation Program) Korea University Grant K1220401
Corresponding Author	Sang Cheul Oh, MD, PhD, Professor of Internal medicine, Division of Oncology/Hematology, Department of Internal Medicine, College of Medicine, Korea University, 148 Gurodong-ro, Guro-gu, Seoul 08308, South Korea. sachoh@korea.ac.kr
Key Words	Advanced gastric cancer; target therapy; chemotherapy; strategy; signal pathway
Core Tip	This review summarizes the development of molecular targeted therapeutic agents in advanced gastric cancer. Agents targeting angiogenesis as well as ERBB receptors and their downstream signaling pathways are introduced. Current efforts to overcome resistance to the human epidermal growth factor receptor 2-targeted agents are also presented from the ongoing clinical trials. Future direction of target therapy should be guided according to further clarification of the molecular mechanisms of gastric cancer and by exploring appropriate indications for application of molecular targeted therapy to improve its efficacy.
Publish Date	2016-01-15 14:54
Citation	Lee S, Oh SC. Changing strategies for target therapy in gastric cancer. World J Gastroenterol 2016; 22(3): 1179-1189
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/1179.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.1179

Full Article (PDF)	WJG-22-1179.pdf
Full Article (Word)	WJG-22-1179.doc
Manuscript File	18945-Review.doc
Answering Reviewers	18945-Answering reviewers.pdf
Audio Core Tip	18945-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18945-Conflict-of-interest statement.pdf
Copyright License Agreement	18945-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18945-Language certificate.pdf
Peer-review Report	18945-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18945-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18945-Scientific misconduct check.pdf
Scientific Editor Work List	18945-Scientific editor work list.pdf