Publication Name	World Journal of Hepatology
Manuscript ID	19006
Country	India

Received	2015-04-30 09:34
Peer-Review Started	2015-05-06 15:42
To Make the First Decision	2015-07-29 10:17
Return for Revision	2015-08-07 16:03
Revised	2015-08-18 18:06
Second Decision	2015-09-21 17:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-30 18:34
Articles in Press	2015-09-30 18:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-08 18:17
Publish the Manuscript Online	2015-10-19 16:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Systematic Reviews
Article Title	Detection of hepatitis B virus infection: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Mallika Ghosh, Srijita Nandi, Shrinwanti Dutta and Malay Kumar Saha
Funding Agency and Grant Number
Corresponding Author	Malay Kumar Saha, PhD, National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM, Beleghata, Kolkata 700010, India. sahamk@yahoo.com
Key Words	Chemiluminescent immunoassay; Serology; Automated detection; Molecular assay; Hepatitis B virus
Core Tip	The article was aimed to review published methods of detection of hepatitis B virus (HBV) infection. A thorough search on medline database was conducted and 72 studies were included. It was observed that HBV can be detected reliably from dried blood spot (sensitivity > 90%). Serological and Molecular assays are predominant and reliable methods. Chemiluminescent immunoassay is more sensitive than Enzyme linked immunosorbent assay. Rapid tests are useful for screening. Real time polymerase chain reaction (PCR), branched DNA probe assays are principal methods for quantitation. Automated systems are more sensitive compared to in house assays. Abbott real time PCR was found to be most sensitive with a lower detection limit of only 1.48 IU/mL.
Publish Date	2015-10-19 16:02
Citation	Ghosh M, Nandi S, Dutta S, Saha MK. Detection of hepatitis B virus infection: A systematic review. World J Hepatol 2015; 7(23): 2482-2491
URL	http://www.wjgnet.com/1948-5182/full/v7/i23/2482.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i23.2482

Full Article (PDF)	WJH-7-2482.pdf
Full Article (Word)	WJH-7-2482.doc
Manuscript File	19006-Review.docx
Answering Reviewers	19006-Answering reviewers.pdf
Audio Core Tip	19006-Audio core tip.mp3
Biostatistics Review Certificate	19006-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19006-Conflict-of-interest statement.pdf
Copyright License Agreement	19006-Copyright assignment.pdf
Peer-review Report	19006-Peer-review(s).pdf
Scientific Misconduct Check	19006-Scientific misconduct check.pdf
Scientific Editor Work List	19006-Scientific editor work list.pdf