| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Twelve-month efficacy and safety of the conversion to everolimus in maintenance heart transplant recipients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nicolás Manito, Juan F Delgado, María G Crespo-Leiro, José María Arizón, Javier Segovia, Francisco González-Vílchez, Sònia Mirabet, Ernesto Lage, Domingo Pascual-Figal, Beatriz Díaz, Jesús Palomo, Gregorio Rábago, Marisa Sanz, Teresa Blasco and Eulàlia Roig |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Novartis Pharma Spain |
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| Corresponding Author |
Nicolás Manito, MD, Heart Failure and Transplant Unit, Department of Cardiology, Hospital de Bellvitge, C/Feixa Llarga s/n, 08907 Barcelona, Spain. nml@csub.scs.es |
| Key Words |
Everolimus; Mammalian target of rapamycin inhibitors; Heart transplantation; Nephrotoxicity; Renal failure |
| Core Tip |
This study is one of the largest multicentre Spanish series of heart transplant recipients converted to everolimus (EVL) reported to date. The results have helped to confirm the efficacy and safety profile of the drug under conditions of routine clinical practice. In the study, conversion to EVL in maintenance phase heart transplant recipients allowed a significant reduction in calcineurin inhibitor treatment with improved kidney function in patients with nephrotoxicity, after one year. Results regarding rejection episodes and EVL discontinuation, suggest that each patient should be individually evaluated for conversion to EVL based on their clinical profile and transplantation evolution. |
| Publish Date |
2015-12-23 08:25 |
| Citation |
Manito N, Delgado JF, Crespo-Leiro MG, Arizón JM, Segovia J, González-Vílchez F, Mirabet S, Lage E, Pascual-Figal D, Díaz B, Palomo J, Rábago G, Sanz M, Blasco T, Roig E. Twelve-month efficacy and safety of the conversion to everolimus in maintenance heart transplant recipients. World J Transplant 2015; 5(4): 310-319 |
| URL |
http://www.wjgnet.com/2220-3230/full/v5/i4/310.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v5.i4.310 |
