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3/2/2016 1:35:00 PM | Browse: 459 | Download: 425
Publication Name World Journal of Gastroenterology
Manuscript ID 19051
Country/Territory Egypt
Received
2015-04-29 21:39
Peer-Review Started
2015-05-07 10:04
To Make the First Decision
2015-08-31 08:30
Return for Revision
2015-09-03 17:21
Revised
2015-09-29 21:52
Second Decision
2015-11-26 16:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-08 16:32
Articles in Press
2015-12-08 16:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-01-18 05:51
Typeset the Manuscript
2016-02-18 20:21
Publish the Manuscript Online
2016-03-02 13:35
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Hend Mohamed El Tayebi and Ahmed Ihab Abdelaziz
Funding Agency and Grant Number
Corresponding author Ahmed Ihab Abdelaziz, MD, PhD, The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City - Main Entrance of Al Tagamoa Al Khames, Cairo 11835, Egypt. ahmed.ihab.abdelaziz@gmail.com
Keywords Hepatocellular carcinoma; Insulin-like growth factors; Insulin-like growth factor receptors; Epigenetics; microRNAs
Core Tip Recent research efforts have focused on targeting the insulin-like growth factor (IGF) axis in an attempt to identify therapeutic options for many health problems. Here, we review the regulation of IGF axis members in hepatocellular carcinoma (HCC), mainly by microRNAs. MicroRNAs work by halting the aberrant expression of the IGF network, as demonstrated by the fact that a single microRNA can have multiple downstream targets in one or more signaling pathways. Use of this approach in an attempt to find an efficient radical cure for HCC.
Publish Date 2016-03-02 13:35
Citation El Tayebi HM, Abdelaziz AI. Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma. World J Gastroenterol 2016; 22(9): 2668-2677
Url http://www.wjgnet.com/1007-9327/full/v22/i9/2668.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i9.2668
Full Article (PDF) WJG-22-2668.pdf
Full Article (Word) WJG-22-2668.doc
Manuscript File 19051-Review.doc
Answering Reviewers 19051-Answering reivewers.pdf
Audio Core Tip 19051-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19051-Conflict-of-interest statement.pdf
Copyright License Agreement 19051-Copyright assignment.pdf
Peer-review Report 19051-Peer-review(s).pdf
Scientific Misconduct Check 19051-Scientific misconduct check.pdf
Scientific Editor Work List 19051-Scientific editor work list.pdf