Publication Name	World Journal of Gastroenterology
Manuscript ID	19051
Country	Egypt

Received	2015-04-29 21:39
Peer-Review Started	2015-05-07 10:04
To Make the First Decision	2015-08-31 08:30
Return for Revision	2015-09-03 17:21
Revised	2015-09-29 21:52
Second Decision	2015-11-26 16:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-08 16:32
Articles in Press	2015-12-08 16:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-01-18 05:51
Typeset the Manuscript	2016-02-18 20:21
Publish the Manuscript Online	2016-03-02 13:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Hend Mohamed El Tayebi and Ahmed Ihab Abdelaziz
Funding Agency and Grant Number
Corresponding Author	Ahmed Ihab Abdelaziz, MD, PhD, The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City - Main Entrance of Al Tagamoa Al Khames, Cairo 11835, Egypt. ahmed.ihab.abdelaziz@gmail.com
Key Words	Hepatocellular carcinoma; Insulin-like growth factors; Insulin-like growth factor receptors; Epigenetics; microRNAs
Core Tip	Recent research efforts have focused on targeting the insulin-like growth factor (IGF) axis in an attempt to identify therapeutic options for many health problems. Here, we review the regulation of IGF axis members in hepatocellular carcinoma (HCC), mainly by microRNAs. MicroRNAs work by halting the aberrant expression of the IGF network, as demonstrated by the fact that a single microRNA can have multiple downstream targets in one or more signaling pathways. Use of this approach in an attempt to find an efficient radical cure for HCC.
Publish Date	2016-03-02 13:35
Citation	El Tayebi HM, Abdelaziz AI. Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma. World J Gastroenterol 2016; 22(9): 2668-2677
URL	http://www.wjgnet.com/1007-9327/full/v22/i9/2668.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i9.2668

Full Article (PDF)	WJG-22-2668.pdf
Full Article (Word)	WJG-22-2668.doc
Manuscript File	19051-Review.doc
Answering Reviewers	19051-Answering reivewers.pdf
Audio Core Tip	19051-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19051-Conflict-of-interest statement.pdf
Copyright License Agreement	19051-Copyright assignment.pdf
Peer-review Report	19051-Peer-review(s).pdf
Scientific Misconduct Check	19051-Scientific misconduct check.pdf
Scientific Editor Work List	19051-Scientific editor work list.pdf