Publication Name	World Journal of Gastroenterology
Manuscript ID	1906
Country	China

Received	2013-01-14 08:38
Peer-Review Started	2013-01-16 14:35
To Make the First Decision	2013-02-26 14:38
Return for Revision	2013-02-27 17:20
Revised	2013-03-08 16:07
Second Decision	2013-03-28 17:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-29 12:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-16 18:34
Publish the Manuscript Online	2013-05-20 14:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation
Manuscript Source	Invited Manuscript
All Author List	Qiu-Ming Wang, Jian-Ling Du, Zhi-Jun Duan, Shi-Bin Guo, Xiao-Yu Sun and Zhen Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30970886 Science and Technology Project of Dalian 2010E15SF179 Initial Doctoral funding of Liaoning Province 20121110
Corresponding Author	Zhi-Jun Duan, Professor, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. cathydoctor@sina.com
Key Words	Heme oxygenase-1; Hepcidin; Iron accumulation; Oxidative stress; Portal vein pressure; Carboxyhemoglobin; Bile duct ligation
Core Tip	In this study, inhibiting heme oxygenase-1 (HO-1)/carbon monoxide (CO) system by zinc protoporphyrin in rat liver fibrosis induced by bile duct ligation, the author aimed to affect the HO-1/CO system by iron deposition and portal pressure. Reducing hepatic iron deposition and CO levels by inhibiting HO-1 activity though the nuclear factor-E2-related factor 2/Keap pathway could be helpful in improving hepatic fibrosis and maintaining portal vein pressure.
Publish Date	2013-05-20 14:33
Citation	Wang QM, Du JL, Duan ZJ, Guo SB, Sun XY, Liu Z. Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. World J Gastroenterol 2013; 19(19): 2921-2934
URL	http://www.wjgnet.com/1007-9327/full/v19/i19/2921.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i19.2921

Full Article (PDF)	WJG-19-2921.pdf
Manuscript File	1906-Review.doc
Answering Reviewers	1906-Answering reviewers.doc
Copyright License Agreement	1906-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1906-Language cetificate.pdf
Peer-review Report	1906-Peer review(s).pdf
Scientific Editor Work List	1906-Scientific editor work list.doc