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Publication Name World Journal of Gastroenterology
Manuscript ID 1906
Country of Manuscript Source China
Received
2013-01-14 08:38
Peer-Review Started
2013-01-16 14:35
To Make the First Decision
2013-02-26 14:38
Return for Revision
2013-02-27 17:20
Revised
2013-03-08 16:07
Second Decision
2013-03-28 17:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-03-29 12:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-05-16 18:34
Publish the Manuscript Online
2013-05-20 14:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation
Manuscript Source Invited Manuscript
All Author List Qiu-Ming Wang, Jian-Ling Du, Zhi-Jun Duan, Shi-Bin Guo, Xiao-Yu Sun and Zhen Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30970886
Science and Technology Project of Dalian 2010E15SF179
Initial Doctoral funding of Liaoning Province 20121110
Corresponding author Zhi-Jun Duan, Professor, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. cathydoctor@sina.com
Keywords Heme oxygenase-1; Hepcidin; Iron accumulation; Oxidative stress; Portal vein pressure; Carboxyhemoglobin; Bile duct ligation
Core Tip In this study, inhibiting heme oxygenase-1 (HO-1)/carbon monoxide (CO) system by zinc protoporphyrin in rat liver fibrosis induced by bile duct ligation, the author aimed to affect the HO-1/CO system by iron deposition and portal pressure. Reducing hepatic iron deposition and CO levels by inhibiting HO-1 activity though the nuclear factor-E2-related factor 2/Keap pathway could be helpful in improving hepatic fibrosis and maintaining portal vein pressure.
Publish Date 2013-05-20 14:33
Citation Wang QM, Du JL, Duan ZJ, Guo SB, Sun XY, Liu Z. Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. World J Gastroenterol 2013; 19(19): 2921-2934
Url http://www.wjgnet.com/1007-9327/full/v19/i19/2921.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i19.2921
Full Article (PDF) WJG-19-2921.pdf
Manuscript File 1906-Review.doc
Answering Reviewers 1906-Answering reviewers.doc
Copyright License Agreement 1906-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 1906-Language cetificate.pdf
Peer-review Report 1906-Peer review(s).pdf
Scientific Editor Work List 1906-Scientific editor work list.doc