Publication Name	World Journal of Hepatology
Manuscript ID	19063
Country	Spain

Received	2015-04-29 21:33
Peer-Review Started	2015-05-07 13:57
To Make the First Decision	2015-09-08 10:35
Return for Revision	2015-09-15 11:08
Revised	2015-11-05 01:57
Second Decision	2016-03-07 15:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-16 16:17
Articles in Press	2016-03-16 16:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-19 18:10
Publish the Manuscript Online	2016-03-24 10:34

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, General & Internal
Manuscript Type	Topic Highlights
Article Title	New advances in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Sonia Pascual, Iván Herrera and Javier Irurzun
Funding Agency and Grant Number
Corresponding Author	Sonia Pascual, MD, Liver Unit, Gastroen­terology Department, Interventional Radiological Unit, Hospital General Universitario de Alicante, C/Pintor Baeza s/n, 03010 Alicante, Spain. pascual_son@gva.es
Key Words	Hepatocellular carcinoma; Surveillance; Staging system; Radiofrequency ablation; Liver surgery; Liver transplant; Transarterial chemoembolization
Core Tip	Liver cancer is the fifth leading cause of cancer worldwide, and the third-leading cause of cancer death. Altouhg some risk factors have been classically associated with development of hepatocell-ular carcinoma (HCC), in the last years, also, some protective factors have been described, like coffee drink, and drugs like statins and beta-blockers. The current European Asso-ciation for the Study of Liver and American Association for the Study of Liver Diseases guidelines recomended the barcelona clinic liver cancer classification as stag-ing system for prognosis prediction and treatment allocation The therapeutic approach in patients with HCC depends on factors such as liver function, tumour extension and comorbidities existence. Available treat-ments are: Surgical treatments, percutaneous ablation, chemoembolization, radioembolization and systemic treatment.
Publish Date	2016-03-24 10:34
Citation	Pascual S, Herrera I, Irurzun J. New advances in hepatocellular carcinoma. World J Hepatol 2016; 8(9): 421-438
URL	http://www.wjgnet.com/1948-5182/full/v8/i9/421.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i9.421

Full Article (PDF)	WJH-8-421.pdf
Full Article (Word)	WJH-8-421.doc
Manuscript File	19063-Review.docx
Answering Reviewers	19063-Answering reviewers.pdf
Audio Core Tip	19063-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19063-Conflict-of-interest statement.pdf
Copyright License Agreement	19063-Copyright assignment.pdf
Peer-review Report	19063-Peer-review(s).pdf
Scientific Misconduct Check	19063-Scientific misconduct check.pdf
Scientific Editor Work List	19063-Scientific editor work list.pdf