Publication Name	World Journal of Gastroenterology
Manuscript ID	19086
Country	United States

Received	2015-04-29 13:10
Peer-Review Started	2015-05-12 08:48
First Decision by Editorial Office Director
Return for Revision	2015-09-29 16:07
Revised	2015-10-18 06:35
Publication Fee Transferred
Second Decision by Editor	2015-11-03 09:21
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-11-13 16:00
Articles in Press	2015-11-13 16:00
Edit the Manuscript by Language Editor	2015-11-17 17:51
Typeset the Manuscript	2015-12-15 15:06
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Topic Highlights
Article Title	Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jason Wachsmann and Fangyu Peng
Funding Agency and Grant Number	Funding Agency Grant Number the Carman and Ann Adams Foundation to Peng F Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Corresponding Author	Fangyu Peng, MD, PhD, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8542, United States. fangyu.peng@utsouthwestern.edu
Key Words	Hepatocellular carcinoma; Positron emission tomography; Copper metabolism; Radionuclide therapy; RNA interference; Gene therapy
Core Tip	Copper is required for cell proliferation and tumor angiogenesis. This article provided an up-to-date review of copper metabolism as a novel theranostic biomarker in hepatocellular carcinoma. Altered copper metabolism is not only a novel biomarker for molecular imaging of extrahepatic metastasis of hepatocellular carcinoma using radioactive copper, but is also a promising target for copper modulation and radionuclide therapy of hepatocellular carcinoma.
Publish Date	2015-12-31 13:27
Citation	Wachsmann J, Peng F. Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma. World J Gastroenterol 2016; 22(1): 221-231
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/221.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.221

Full Article (PDF)	WJG-22-221.pdf
Full Article (Word)	WJG-22-221.doc
Manuscript File	19086-Review.docx
Answering Reviewers	19086-Answering reviewers.pdf
Audio Core Tip	19086-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	19086-Conflict-of-interest statement.pdf
Copyright License Agreement	19086-Copyright assignment.pdf
Peer-review Report	19086-Peer-review(s).pdf
Scientific Misconduct Check	19086-Scientific misconduct check.pdf
Scientific Editor Work List	19086-Scientific editor work list.pdf