Publication Name	World Journal of Gastroenterology
Manuscript ID	19092
Country	United States

Received	2015-04-30 11:01
Peer-Review Started	2015-05-12 10:07
To Make the First Decision	2015-08-26 10:03
Return for Revision	2015-08-26 18:22
Revised	2015-10-06 03:14
Second Decision	2015-11-11 16:55
Accepted by Journal Editor-in-Chief	2015-11-11 21:57
Accepted by Company Editor-in-Chief	2015-11-24 16:47
Articles in Press	2015-11-24 16:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-15 16:00
Publish the Manuscript Online	2016-01-20 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Is irritable bowel syndrome an infectious disease?
Manuscript Source	Invited Manuscript
All Author List	John Richard Thompson
Funding Agency and Grant Number
Corresponding Author	John Richard Thompson, PhD, MBA, Professor, Chair, Department of Pharmacy Practice, Lipscomb University College of Pharmacy, One University Park Drive, Nashville, TN 37204, United States. richard.thompson@lipscomb.edu
Key Words	irritable bowel syndrome; pathopohysiology; etiology; Probiotics; antibiotics; infectious disease
Core Tip	Recent evidence from both basic and clinical science supports the hypothesis of infectious disease as an etiological agent in irritable bowel syndrome (IBS). The presence of small intestinal bowel overgrowth and its treatment as reflected in reductions of lactulose hydrogen breath tests correlates with improvement in IBS symptoms. Clinical trials with both probiotics and antibiotics also appear to relieve symptoms of IBS and have a sustained effect post-treatment. Recurrences of symptoms post-treatment appear to respond similarly with no loss of effect. An infectious disease etiology of IBS may explain the heterogeneous symptoms of the disease and varying responses seen with different symptom phenotypes.
Publish Date	2016-01-20 16:55
Citation	Thompson JR. Is irritable bowel syndrome an infectious disease? World J Gastroenterol 2016; 22(4): 1331-1334
URL	http://www.wjgnet.com/1007-9327/full/v22/i4/1331.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i4.1331

Full Article (PDF)	WJG-22-1331.pdf
Full Article (Word)	WJG-22-1331.doc
Manuscript File	19092-Review.docx
Answering Reviewers	19092-Answering reviewers.pdf
Audio Core Tip	19092-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19092-Conflict-of-interest statement.pdf
Copyright License Agreement	19092-Copyright assignment.pdf
Peer-review Report	19092-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19092-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19092-Scientific misconduct check.pdf
Scientific Editor Work List	19092-Scientific editor work list.pdf