Publication Name	World Journal of Gastroenterology
Manuscript ID	1912
Country	China

Received	2013-01-14 09:19
Peer-Review Started	2013-01-16 14:59
First Decision by Editorial Office Director
Return for Revision	2013-02-27 17:49
Revised
Publication Fee Transferred
Second Decision by Editor	2013-05-22 09:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-05-22 10:32
Articles in Press
Edit the Manuscript by Language Editor	2013-05-28 16:01
Typeset the Manuscript	2013-06-07 09:27
Publish the Manuscript Online	2013-06-14 23:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Role of nesfatin-1 in a rat model of visceral hypersensitivity
Manuscript Source	Invited Manuscript
All Author List	Fang-Yuan Jia, Xue-Liang Li, Tian-Nv Li, Jing Wu, Bi-Yun Xie and Lin Lin
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81070308/H0308
Corresponding Author	Xue-Liang Li, MD, PhD, Professor, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. ligakur@yahoo.com.cn
Key Words	Irritable bowel syndrome; Nesfatin-1; Visceral hypersensitivity; Corticotropin releasing factor; Intracerebroventricular injection
Core Tip	This is a well conducted experimental study on the possible effect of nesfatin-1 in visceral hypersensitivity. Currently no reports have been published concerning the role of nesfatin-1 in irritable bowel syndrome (IBS). In a well-established visceral hypersensitivity animal model, we found an elevated nesfatin-1 level in the serum, and there was a reduction in evoked abdominal electromyography and abdominal withdrawal reflex scores after treatment with nesfatin-1 antibody, a non-selective corticotropin releasing factor (CRF) receptor antagonist, or a selective CRF1 receptor antagonist. These results suggest that nesfatin-1 may be associated with visceral hypersensitivity in model rats and implicated in brain CRF/CRF1 signaling pathways, which contribute to the visceral hypersensitivity of IBS.
Publish Date	2013-06-14 23:10
Citation	Jia FY, Li XL, Li TN, Wu J, Xie BY, Lin L. Role of nesfatin-1 in a rat model of visceral hypersensitivity. World J Gastroenterol 2013; 19(22): 3487-3493
URL	http://www.wjgnet.com/1007-9327/full/v19/i22/3487.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i22.3487

Full Article (PDF)	WJG-19-3487.pdf
Manuscript File	1912-Review.doc
Answering Reviewers	1912-Answering reviewers.doc
Copyright License Agreement	1912-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics Committee Approval Document.doc
Non-Native Speakers of English Editing Certificate	1912-Language cetificate.pdf
Peer-review Report	1912-Peer review.pdf
Scientific Editor Work List	1912-Scientific editor work list.doc