Publication Name	World Journal of Gastroenterology
Manuscript ID	19147
Country	China

Received	2015-04-29 12:27
Peer-Review Started	2015-05-08 07:47
To Make the First Decision	2015-07-19 15:33
Return for Revision	2015-07-27 11:21
Revised	2015-08-24 21:08
Second Decision	2015-10-12 09:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-20 09:48
Articles in Press	2015-10-20 09:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-10-27 11:41
Typeset the Manuscript	2015-12-04 14:44
Publish the Manuscript Online	2015-12-15 12:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Juan-Juan Shi, Xiao-Li Jia, Mei Li, Ning Yang, Ya-Ping Li, Xin Zhang, Ning Gao and Shuang-Suo Dang
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Foundation of Shaanxi Province, China 2007K16-07(9)
Corresponding Author	Xiao-Li Jia, PhD, Department of Infectious Diseases, the Second Affiliated Hospital of Medical School of Xi’an Jiaotong University, No. 157 Xi’wu Road, Xi’an 710004, Shaanxi Province, China. drjxl@163.com
Key Words	Guggulsterone; Hepatocellular carcinoma cells; Apoptosis; Cell cycle; Mitochondrial pathway
Core Tip	Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and the second leading cause of tumor mortality worldwide. Guggulsterone (GS) is a phytosterol extracted from the gum resin of guggul plants, and its pro-apoptotic effect has been found to play a pivotal role in its anti-carcinogenic mechanisms. In this study, we investigated the anticancer effects of GS-induced apoptosis in human HCC cells and the underlying molecular mechanisms. Our results demonstrated that GS induced HepG2 cell apoptosis through regulating Bcl-2 and Bax expression levels.
Publish Date	2015-12-15 12:22
Citation	Shi JJ, Jia XL, Li M, Yang N, Li YP, Zhang X, Gao N, Dang SS. Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway. World J Gastroenterol 2015; 21(47): 13277-13287
URL	http://www.wjgnet.com/1007-9327/full/v21/i47/13277.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i47.13277

Full Article (PDF)	WJG-21-13277.pdf
Full Article (Word)	WJG-21-13277.doc
Manuscript File	19147-Review.docx
Answering Reviewers	19147-Answering reviewers.pdf
Audio Core Tip	19147-Audio core tip.mp3
Biostatistics Review Certificate	19147-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19147-Conflict-of-interest statement.pdf
Copyright License Agreement	19147-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19147-Language certificate.pdf
Peer-review Report	19147-Peer-review(s).pdf
Scientific Misconduct Check	19147-Scientific misconduct check.pdf
Scientific Editor Work List	19147-Scientific editor work list.pdf