Publication Name	World Journal of Gastroenterology
Manuscript ID	19177
Country	Germany

Received	2015-04-29 17:11
Peer-Review Started	2015-05-08 10:08
To Make the First Decision	2015-08-25 16:03
Return for Revision	2015-08-26 16:28
Revised	2015-09-24 21:26
Second Decision	2015-11-02 09:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-13 17:22
Articles in Press	2015-11-13 17:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-17 14:18
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance
Manuscript Source	Invited Manuscript
All Author List	Christoph G Dietrich, Oliver Götze and Andreas Geier
Funding Agency and Grant Number
Corresponding Author	Christoph G Dietrich, MD, PhD, Bethlehem Center of Health, Department of Internal Medicine, Bethlehem-Gesundheitszentrum, Steinfeldstrasse 5, D-52222 Stolberg (Rhineland), Germany. dietrich@bethlehem.de
Key Words	liver cirrhosis; drug metabolism; transport; breath tests; lipid metabolism; glucose metabolism
Core Tip	Liver cirrhosis is a common endpoint for many hepatic diseases and is accompanied by the extensive gene regulation of cytokines and enzymes for hepatic metabolism. The resulting organ deficiency complicates treatment decisions, especially regarding transplantation and the resection of hepatocellular carcinoma. This review summarizes the regulatory events involving the metabolism in the cirrhotic liver and puts these events into the context of the non-invasive testing of liver function. This combination can help to better estimate the liver function of individual patients.
Publish Date	2015-12-31 13:27
Citation	Dietrich CG, Götze O, Geier A. Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance. World J Gastroenterol 2016; 22(1): 72-88
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/72.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.72

Full Article (PDF)	WJG-22-72.pdf
Full Article (Word)	WJG-22-72.doc
Manuscript File	19177-Review.docx
Answering Reviewers	19177-Answering reviewers.pdf
Audio Core Tip	19177-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19177-Conflict-of-interest statement.pdf
Copyright License Agreement	19177-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19177-Language certificate.pdf
Peer-review Report	19177-Peer-review(s).pdf
Scientific Misconduct Check	19177-Scientific misconduct check.pdf
Scientific Editor Work List	19177-Scientific editor work list.pdf