Publication Name	World Journal of Biological Chemistry
Manuscript ID	1919
Country	United States

Received	2013-01-14 09:33
Peer-Review Started	2013-01-14 19:52
First Decision by Editorial Office Director
Return for Revision	2013-02-25 11:00
Revised	2013-03-19 21:31
Publication Fee Transferred
Second Decision by Editor	2013-04-28 14:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-04-29 01:00
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-04 11:07
Publish the Manuscript Online	2013-05-10 17:28

ISSN	1949-8454 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Autobiography
Article Title	Refractoriness of interferon-beta signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound
Manuscript Source	Invited Manuscript
All Author List	Zaifang Yu, Jarrod D Predina and Guanjun Cheng
Funding Agency and Grant Number	Funding Agency Grant Number NCI PO1 CA 66726
Corresponding Author	Dr. Guanjun Cheng, Thoracic Oncology Research Laboratory, 1016B ARC, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, United States. guanjun@mail.med.upenn.edu
Key Words	Innate immunity; Interferon; Refractoriness; Xanthone; Bronchial epithelium
Core Tip	We recently demonstrated that a small, cell-permeable compound, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), was able to induce production of interferon (IFN)-? and IFN-?-dependent proteins and protect epithelial cells in vitro from virally-induced cell death and to protect mice from a lethal dose of H1N1 influenza A virus. DMXAA that activates multiple antiviral pathways including IFN-? pathway is an attractive strategy in antiviral therapies. Nucleotide oligomerization domain 1 pathway may play an important role in refractoriness of IFN-? signaling in mouse respiratory epithelial cells induced by DMXAA.
Publish Date	2013-05-10 17:28
Citation	Yu Z, Predina JD, Cheng G. Refractoriness of interferon-b signaling through NOD1 pathway in mouse respiratory epithelial cells using the anticancer xanthone compound. World J Biol Chem 2013; 4(2): 18-29
URL	http://www.wjgnet.com/1949-8454/full/v4/i2/18.htm
DOI	http://dx.doi.org/10.4331/wjbc.v4.i2.18

Full Article (PDF)	WJBC-4-18.pdf
Manuscript File	1919-Review.doc
Answering Reviewers	1919-Answering reviewers.pdf
Copyright License Agreement	1919-Copyright assignment.pdf
Peer-review Report	1919-Peer reviews.pdf
Scientific Editor Work List	1919-Scientific editor work list.doc