Publication Name	World Journal of Radiology
Manuscript ID	19193
Country	Canada

Received	2015-04-30 13:32
Peer-Review Started	2015-04-30 21:08
First Decision by Editorial Office Director
Return for Revision	2015-10-28 13:33
Revised	2015-11-05 23:20
Publication Fee Transferred
Second Decision by Editor	2015-11-23 17:56
Second Decision by Editor-in-Chief	2015-11-23 21:37
Final Decision by Editorial Office Director	2015-12-04 16:07
Articles in Press	2015-12-04 16:07
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-15 16:29
Publish the Manuscript Online	2016-01-26 17:37

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Leakage-Penumbra effect in intensity modulated radiation therapy step-and-shoot dose delivery
Manuscript Source	Invited Manuscript
All Author List	Grigor N Grigorov and James CL Chow
Funding Agency and Grant Number
Corresponding Author	James CL Chow, PhD, Radiation Medicine Program, Princess Margaret Cancer Center, 610 University Avenue, Toronto, ON M5G 2M9, Canada. james.chow@rmp.uhn.on.ca
Key Words	Multileaf collimator leakage; Overshoot effect; Beam penumbra; Prostate intensity modulated radiation therapy planning
Core Tip	This manuscript contains discussion of the effect of inter-leaf leakage in multileaf collimator (MLC)-based step-and-shoot intensity-modulated radiotherapy (IMRT) of cancer, and presents a method to measure and correct for this effect. Based on our experience, and as illustrated with a single IMRT plan, we recommend adjusting the width of treatment field for different segments delivered in the step-and-shoot fashion (to reduce overlap effects), and possibly, to include leakage as optimization parameter in treatment planning. In this study, we introduced a novel empirical model for determining the 2-dimensional distribution of dose resulting from transmission through the MLC.
Publish Date	2016-01-26 17:37
Citation	Grigorov GN, Chow JCL. Leakage-Penumbra effect in intensity modulated radiation therapy step-and-shoot dose delivery. World J Radiol 2016; 8(1): 73-81
URL	http://www.wjgnet.com/1949-8470/full/v8/i1/73.htm
DOI	http://dx.doi.org/10.4329/wjr.v8.i1.73

Full Article (PDF)	WJR-8-73.pdf
Full Article (Word)	WJR-8-73.doc
Manuscript File	19193-Review.docx
Answering Reviewers	19193-Answering reviewers.pdf
Audio Core Tip	19193-Audio core tip.mp3
Biostatistics Review Certificate	19193-Biostatics statement.pdf
Conflict-of-Interest Disclosure Form	19193-Conflict-of-interest statement.pdf
Copyright License Agreement	19193-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	19193-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	19193-Institutional review board statement.pdf
Peer-review Report	19193-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19193-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19193-Scientific misconduct check.pdf
Scientific Editor Work List	19193-Scientific editor work list.pdf