Publication Name	World Journal of Gastroenterology
Manuscript ID	19204
Country	France

Received	2015-04-30 13:11
Peer-Review Started	2015-05-07 17:16
To Make the First Decision	2015-06-23 15:00
Return for Revision	2015-06-26 17:06
Revised	2015-09-27 19:20
Second Decision	2015-11-12 18:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-01 08:27
Articles in Press	2015-12-01 08:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-10 09:14
Publish the Manuscript Online	2016-01-21 16:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	One hundred and one over-the-scope-clip applications for severe gastrointestinal bleeding, leaks and fistulas
Manuscript Source	Invited Manuscript
All Author List	Edris Wedi, Susana Gonzalez, Detlev Menke, Elena Kruse, Kai Matthes and Juergen Hochberger
Funding Agency and Grant Number	Funding Agency Grant Number “Endo-Verein Erlangen”
Corresponding Author	Juergen Hochberger, MD, PhD, Pro­fessor, Chairman, Section of Gastroenterology and GI Endoscopy, Interdisciplinary Center for Digestive Diseases, Strasbourg University Hospitals, Nouvel Hôpital Civil and IHU, 1, place de l’Hôpital, F-67091 Strasbourg, France. juehochber@mac.com
Key Words	Over-the-scope-clip; Endoscopic therapy; Gastrointestinal bleeding; Perforation; Fistula
Core Tip	In this retrospective study a novel endoscopic over-the-scope-clip (OTSC) was evaluated for the treatment of severe gastrointestinal bleeding, perforation and fistula. 101 OTSCs were applied in 84 patients with a primary clinical success in 75/84 patients for all applications corresponding to 89%. Severe bleeding was successfully treated in 35/41 patients with upper gastrointestinal (GI) bleeding (85.36%) and in all 3 patients with severe lower GI bleeding. Technical success of perforation closure was 100% while clinical success was seen in 4/7 cases (57.14%) due to attendant circumstances unrelated to the OTSC. Technical and clinic success was achieved in 18/18 patients for the prevention of secondary perforation or bleeding after endoscopic mucosal resection and endoscopic submucosal dissection and in 3/3 fistula closures. Two application-related complications were seen. This largest single center experience published so far confirms the high value of the OTSC for the endoscopic treatment of GI emergencies and complications.
Publish Date	2016-01-21 16:10
Citation	Wedi E, Gonzalez S, Menke D, Kruse E, Matthes K, Hochberger J. One hundred and one over-the-scope-clip applications for severe gastrointestinal bleeding, leaks and fistulas. World J Gastroenterol 2016; 22(5): 1844-1853
URL	http://www.wjgnet.com/1007-9327/full/v22/i5/1844.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i5.1844

Full Article (PDF)	WJG-22-1844.pdf
Full Article (Word)	WJG-22-1844.doc
Manuscript File	19204-Review.doc
Answering Reviewers	19204-Answering reviewers.pdf
Audio Core Tip	19204-Audio core tip.mp3
Biostatistics Review Certificate	19204-Biostatistics statement.pdf
Copyright License Agreement	19204-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	19204-Institutional review board statement.pdf
Video	19204-Video core tip.m4v
Peer-review Report	19204-Peer-review(s).pdf
Scientific Misconduct Check	19204-Scientific misconduct check.pdf
Scientific Editor Work List	19204-Scientific editor work list.pdf