Publication Name	World Journal of Hepatology
Manuscript ID	19211
Country	United States

Received	2015-04-30 13:01
Peer-Review Started	2015-05-07 18:00
To Make the First Decision	2015-06-29 18:15
Return for Revision	2015-07-01 08:52
Revised	2015-07-28 11:14
Second Decision	2015-08-13 10:09
Accepted by Journal Editor-in-Chief	2015-08-13 13:10
Accepted by Executive Editor-in-Chief	2015-08-21 16:08
Articles in Press	2015-08-21 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-26 08:51
Publish the Manuscript Online	2015-09-09 14:44

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Chronic hepatitis E: A brief review
Manuscript Source	Invited Manuscript
All Author List	Arvind R Murali, Vikram Kotwal and Saurabh Chawla
Funding Agency and Grant Number
Corresponding Author	Saurabh Chawla, MD, Assistant Professor of Medicine, Director of Interventional Endoscopy, Grady Memorial Hospital and Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Faculty Office Building, 49 Jesse Hill Jr. Drive, Suite 431, Atlanta, GA 30322, United States. saurabh.chawla@emory.edu
Key Words	Hepatitis E virus; Chronic liver disease; Solid organ transplantation; Hematological malignancies; Immunosuppression
Core Tip	Chronic hepatitis E occurs mainly in immuno-suppressed individuals such as transplant recipients, human immunodeficiency virus patients with low CD4 counts and in patients with hematological maligna-ncies receiving chemotherapy. A few cases have also been reported in immunocompetent individuals. These patients may present with unexplained elevation in transaminases or less frequently with neurological or renal manifestations. The diagnosis is confirmed by a persistent elevation of hepatitis E RNA in serum or stool. Reduction of immunosuppression to achieve spontaneous viral clearance should be attempted. However it is effective only in about a third of patients, therefore most patients require treatment with antiviral agents, like ribavirin. The purpose of this review is to increase awareness amongst physicians of chronic hepatitis E infection as a possible treatable cause of chronic liver disease, especially in immunosuppressed individuals.
Publish Date	2015-09-09 14:44
Citation	Murali AR, Kotwal V, Chawla S. Chronic hepatitis E: A brief review. World J Hepatol 2015; 7(19): 2194-2201
URL	http://www.wjgnet.com/1948-5182/full/v7/i19/2194.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i19.2194

Full Article (PDF)	WJH-7-2194.pdf
Full Article (Word)	WJH-7-2194.doc
Manuscript File	19211-Review.docx
Answering Reviewers	19211-Answering reviewers.pdf
Audio Core Tip	19211-Audio core tip.wma
Conflict-of-Interest Disclosure Form	19211-Conflict-of-interest statement.pdf
Copyright License Agreement	19211-Copyright assignment.pdf
Peer-review Report	19211-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19211-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19211-Scientific misconduct check.pdf
Scientific Editor Work List	19211-Scientific editor work list.pdf