Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	19260
Country	Japan

Received	2015-05-03 12:17
Peer-Review Started	2015-05-08 16:22
To Make the First Decision	2015-07-17 16:37
Return for Revision	2015-07-22 17:24
Revised	2015-07-28 17:12
Second Decision	2015-09-02 10:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-16 18:37
Articles in Press	2015-09-16 18:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-10 20:16
Publish the Manuscript Online	2015-10-19 09:39

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Genomic alterations in pancreatic cancer and their relevance to therapy
Manuscript Source	Invited Manuscript
All Author List	Erina Takai and Shinichi Yachida
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Science and Culture of Japan 26870874 (to Takai E) Ministry of Education, Science and Culture of Japan 25134719 (to Yachida S) National Cancer Center Research and Development Fund 25-A-3 (to Takai E and Yachida S) Takeda Science Foundation to Yachida S Uehara Memorial Foundation to Yachida S Mochida Memorial Foundation to Yachida S Medical Research Encouragement Prize of the Japan Medical Association to Yachida S Pancreas Research Foundation of Japan to Yachida S Princess Takamatsu Cancer Research Fund to Yachida S
Corresponding Author	Erina Takai, PhD, Division of Cancer Genomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ertakai@ncc.go.jp
Key Words	Pancreatic cancer; Genomic alterations; Signaling pathways; Therapeutic targets; Personalized medicine
Core Tip	With the advance of sequencing technologies for global genomic analysis, the landscape of genomic alterations in pancreatic cancer is becoming increasingly well understood. In this review, we summarize the latest knowledge of genomic alterations in pancreatic ductal adenocarcinoma including commonly mutated genes and many other genes that are mutated at low frequencies. We also describe the potential implications of these genomic alterations for development of novel therapeutic approaches in the context of personalized medicine.
Publish Date	2015-10-19 09:39
Citation	Takai E, Yachida S. Genomic alterations in pancreatic cancer and their relevance to therapy. World J Gastrointest Oncol 2015; 7(10): 250-258
URL	http://www.wjgnet.com/1948-5204/full/v7/i10/250.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i10.250

Full Article (PDF)	WJGO-7-250.pdf
Full Article (Word)	WJGO-7-250.doc
Manuscript File	19260-Review.docx
Answering Reviewers	19260-Answering reviewers.pdf
Audio Core Tip	19260-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19260-Conflict-of-interest statement.PDF
Copyright License Agreement	19260-Copyright assignment.pdf
Peer-review Report	19260-Peer-review(s).pdf
Scientific Misconduct Check	19260-Scientific misconduct check.pdf
Scientific Editor Work List	19260-Scientific editor work list.pdf