Publication Name	World Journal of Gastroenterology
Manuscript ID	1929
Country	China

Received	2013-01-15 09:29
Peer-Review Started	2013-01-15 16:00
To Make the First Decision	2013-03-04 13:43
Return for Revision	2013-03-05 10:27
Revised	2013-03-15 21:14
Second Decision	2013-04-09 20:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-10 07:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-17 20:36
Publish the Manuscript Online	2013-05-28 09:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Risk factors for proton pump inhibitor refractoriness in Chinese patients with non-erosive reflux disease
Manuscript Source	Invited Manuscript
All Author List	Xiao-Ping Niu, Bao-Ping Yu, Yun-Dong Wang, Zhen Han, Shao-Fen Liu, Chi-Yi He, Guo-Zheng Zhang and Wan-Chun Wu
Funding Agency and Grant Number
Corresponding Author	Bao-Ping Yu, MD, Department of Gastroenterology, Renmin Hospital, Wuhan University, No. 99 Zhangzhidong Road, Wuchang District, Wuhan 430060, Hubei Province, China. baopingyu@yahoo.cn
Key Words	Risk factors; Refractoriness; Proton pump inhibitors; Non-erosive reflux disease
Core Tip	Non-erosive reflux disease (NERD) is significantly more refractory to proton pump inhibitor (PPI) treatment than erosive esophagitis is, although the reason is unclear at present. Here, we investigated the risk factors for refractoriness to PPI treatment in patients with NERD. Our results demonstrate that some NERD patients are refractory to standard doses of PPIs and have a lower quality of life. Residual symptoms are associated with psychological distress, intestinal disorders, and low body mass index. Recognition of this might hold the key to improving long-term management of NERD.
Publish Date	2013-05-28 09:36
Citation	Niu XP, Yu BP, Wang YD, Han Z, Liu SF, He CY, Zhang GZ, Wu WC. Risk factors for proton pump inhibitor refractoriness in Chinese patients with non-erosive reflux disease. World J Gastroenterol 2013; 19(20): 3124-3129
URL	http://www.wjgnet.com/1007-9327/full/v19/i20/3124.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i20.3124

Full Article (PDF)	WJG-19-3124.pdf
Manuscript File	1929-Review.doc
Answering Reviewers	1929-Answering reviewers.doc
Copyright License Agreement	1929-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	1929-Language certificate.doc
Peer-review Report	1929-Peer review(s).pdf
Scientific Editor Work List	1929-Scientific editor work list.doc