Publication Name	World Journal of Gastroenterology
Manuscript ID	19309
Country	China

Received	2015-05-05 10:26
Peer-Review Started	2015-05-05 10:46
To Make the First Decision	2015-06-03 09:29
Return for Revision	2015-06-06 19:39
Revised	2015-07-13 23:59
Second Decision	2015-08-19 14:56
Accepted by Journal Editor-in-Chief	2015-08-19 23:25
Accepted by Company Editor-in-Chief	2015-09-01 14:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-05 16:46
Typeset the Manuscript	2015-09-08 16:29
Publish the Manuscript Online	2015-09-28 11:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Chemoembolization alone vs combined chemoembolization and hepatic arterial infusion chemotherapy in inoperable hepatocellular carcinoma patients
Manuscript Source	Unsolicited Manuscript
All Author List	Song Gao, Peng-Jun Zhang, Jian-Hai Guo, Hui Chen, Hai-Feng Xu, Peng Liu, Ren-Jie Yang and Xu Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Capital Health Development Special Scientific Research Projects 2014-2-2154 Single Center Prospective Study NCT01997957
Corresponding Author	Xu Zhu, MD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital & Institute, Beijing 100142, China. drzhuxu@163.com
Key Words	Chemoembolization; Hepatic arterial infusion chemotherapy; Oxaliplatin; Hepatocellular carcinoma
Core Tip	Eighty-four inoperable hepatocellular carcinoma (HCC) patients were enrolled, 39 patients underwent chemoembolization alone, and the other 45 patients underwent chemoembolization + hepatic arterial infusion chemotherapy (HAIC) [oxaliplatin (OXA)/5-fluorouracil (5-FU)/folinic acid (CF)] treatment non-randomly. The progression free survival (PFS), objective response rate (ORR), disease control rate (DCR) and adverse reactions were compared between the two groups. A significant difference in the ORR was observed between the two groups. There was no statistically significant difference in DCR between the two groups. The median PFS (mPFS) showed a significant difference between the two groups. For patients with BCLC stage A/B disease, with or without vessel invasion, the chemoembolization + HAIC group showed better mPFS when compared to chemoembolization alone, but no significant difference was found in patients with BCLC stage C disease. The parameter of pain (grade Ⅲ-Ⅳ) in the chemoembolization + HAIC group was increased statistically. Chemoembolization combined with HAIC with OXA/5-FU/CF may be safe and more effective than chemoembolization alone for inoperable HCC patients without distant metastases.
Publish Date	2015-09-28 11:42
Citation	Gao S, Zhang PJ, Guo JH, Chen H, Xu HF, Liu P, Yang RJ, Zhu X. Chemoembolization alone vs combined chemoembolization and hepatic arterial infusion chemotherapy in inoperable hepatocellular carcinoma patients. World J Gastroenterol 2015; 21(36): 10443-10452
URL	http://www.wjgnet.com/1007-9327/full/v21/i36/10443.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i36.10443

Full Article (PDF)	WJG-21-10443.pdf
Full Article (Word)	WJG-21-10443.doc
Manuscript File	19309-Review.doc
Answering Reviewers	19309-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	19309-Conflict-of-interest statement.pdf
Copyright License Agreement	19309-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19309-Language certificate.pdf
Peer-review Report	19309-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19309-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19309-Scientific misconduct check.pdf
Scientific Editor Work List	19309-Scientific editor work list.pdf