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Articles Published Processes
10/23/2015 3:58:00 PM | Browse: 1242 | Download: 2121
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Received |
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2015-05-04 16:51 |
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Peer-Review Started |
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2015-05-09 15:54 |
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To Make the First Decision |
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2015-06-02 16:00 |
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Return for Revision |
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2015-06-09 12:44 |
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Revised |
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2015-06-17 00:00 |
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Second Decision |
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2015-08-06 21:21 |
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Accepted by Journal Editor-in-Chief |
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2015-08-07 01:07 |
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Accepted by Executive Editor-in-Chief |
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2015-08-31 17:54 |
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Articles in Press |
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2015-08-31 17:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-12 17:50 |
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Publish the Manuscript Online |
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2015-10-23 15:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Hidetoshi Eguchi, Katsuyoshi Matsunami, Kiyomi Taniyama, Nobutaka Hatanaka, Hiroki Akamatsu, Masaki Mori and Yuichiro Doki |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Sports and Culture of Japan |
25462129（to M. T.） |
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| Corresponding Author |
Masahiro Tanemura, MD, PhD, Department of Surgery, Osaka Police Hospital, 10-31 Kitayamacho Tennoujiku, Osaka 543-0035, Japan. tanemuram@oph.gr.jp
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| Key Words |
Pancreatic cancer; Immunotherapy; Cancer antigen; MUC1; α-gal epitopes; Cancer vaccine; Cancer stem cell; Carbohydrate research |
| Core Tip |
The goal of cancer immunotherapy is to elicit an immune response against autologous tumors and to induce multiple T cell clones against multiple tumor-associated antigens. To establish effective, next-generation immunotherapy toward pancreatic ductal adenocarcinoma (PDAC), we focus on the strong interaction between the natural human antibody, anti-Gal, and carbohydrate antigens called “α-gal epitopes”. Here, we review the literature on the distribution of natural anti-Gal antibody and its ligand in mammals and characterization of the immunosuppressive microenvironment of PDAC tumors, which is a major obstacle against effective clinical immunotherapies. We also discuss immunotherapeutic strategies using the α-gal epitope/anti-Gal antibody reaction.
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| Publish Date |
2015-10-23 15:45 |
| Citation |
Tanemura M, Miyoshi E, Nagano H, Eguchi H, Matsunami K, Taniyama K, Hatanaka N, Akamatsu H, Mori M, Doki Y. Cancer immunotherapy for pancreatic cancer utilizing -gal epitope/natural anti-Gal antibody reaction. World J Gastroenterol 2015; 21(40): 11396-11410 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i40/11396.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i40.11396 |
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