Publication Name	World Journal of Gastroenterology
Manuscript ID	19314
Country	Japan

Received	2015-05-04 16:51
Peer-Review Started	2015-05-09 15:54
First Decision by Editorial Office Director
Return for Revision	2015-06-09 12:44
Revised	2015-06-17 00:00
Publication Fee Transferred
Second Decision by Editor	2015-08-06 21:21
Second Decision by Editor-in-Chief	2015-08-07 01:07
Final Decision by Editorial Office Director	2015-08-31 17:54
Articles in Press	2015-08-31 17:54
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-12 17:50
Publish the Manuscript Online	2015-10-23 15:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Topic Highlights
Article Title	Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction
Manuscript Source	Invited Manuscript
All Author List	Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Hidetoshi Eguchi, Katsuyoshi Matsunami, Kiyomi Taniyama, Nobutaka Hatanaka, Hiroki Akamatsu, Masaki Mori and Yuichiro Doki
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Sports and Culture of Japan 25462129（to M. T.）
Corresponding Author	Masahiro Tanemura, MD, PhD, Depart­ment of Surgery, Osaka Police Hospital, 10-31 Kitayamacho Tennoujiku, Osaka 543-0035, Japan. tanemuram@oph.gr.jp
Key Words	Pancreatic cancer; Immunotherapy; Cancer antigen; MUC1; α-gal epitopes; Cancer vaccine; Cancer stem cell; Carbohydrate research
Core Tip	The goal of cancer immunotherapy is to elicit an immune response against autologous tumors and to induce multiple T cell clones against multiple tumor-associated antigens. To establish effective, next-generation immunotherapy toward pancreatic ductal adenocarcinoma (PDAC), we focus on the strong interaction between the natural human antibody, anti-Gal, and carbohydrate antigens called “α-gal epitopes”. Here, we review the literature on the distribution of natural anti-Gal antibody and its ligand in mammals and characterization of the immunosuppressive microenvironment of PDAC tumors, which is a major obstacle against effective clinical immunotherapies. We also discuss immunotherapeutic strategies using the α-gal epitope/anti-Gal antibody reaction.
Publish Date	2015-10-23 15:45
Citation	Tanemura M, Miyoshi E, Nagano H, Eguchi H, Matsunami K, Taniyama K, Hatanaka N, Akamatsu H, Mori M, Doki Y. Cancer immunotherapy for pancreatic cancer utilizing -gal epitope/natural anti-Gal antibody reaction. World J Gastroenterol 2015; 21(40): 11396-11410
URL	http://www.wjgnet.com/1007-9327/full/v21/i40/11396.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i40.11396

Full Article (PDF)	WJG-21-11396.pdf
Full Article (Word)	WJG-21-11396.doc
Manuscript File	19314-Reveiw.doc
Answering Reviewers	19314-Answering reviewers.pdf
Audio Core Tip	19314-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19314-Conflict-of-interest statement.pdf
Copyright License Agreement	19314-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19314-Language certificate.pdf
Peer-review Report	19314-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19314-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19314-Scientific misconduct check.pdf
Scientific Editor Work List	19314-Scientific editor work list.pdf