Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	19328
Country	United States

Received	2015-05-05 08:45
Peer-Review Started	2015-05-06 08:03
To Make the First Decision	2015-07-03 16:52
Return for Revision	2015-07-10 11:14
Revised	2015-08-08 00:02
Second Decision	2015-08-13 10:09
Accepted by Journal Editor-in-Chief	2015-08-13 12:38
Accepted by Executive Editor-in-Chief	2015-08-21 16:09
Articles in Press	2015-08-21 16:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-22 10:25
Publish the Manuscript Online	2015-11-12 18:51

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Present state and future challenges in pediatric abdominal pain therapeutics research: Looking beyond the forest
Manuscript Source	Invited Manuscript
All Author List	Craig A Friesen, Jennifer V Schurman and Susan M Abdel-Rahman
Funding Agency and Grant Number
Corresponding Author	Craig A Friesen, MD, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Mercy Kansas City, 2401 Gillham Road, Kansas City, MO 64108, United States. cfriesen@cmh.edu
Key Words	Abdominal pain; Functional dyspepsia; Irritable bowel syndrome; Therapeutic trials; Pharmacokinetics; Pharmacogenomics
Core Tip	For abdominal pain therapeutics research to fulfill the promise of personalized medicine, there is a need to standardize trial entry criteria including validating Rome criteria as predictors of response. There is also a need to embrace complexity and recognize and control for the large number of biologic, psychologic, social, and pharmacologic factors which define each patient and may affect drug response. This approach will allow us not only to understand what treatments work for the population at large, but for the individual patient in front of us.
Publish Date	2015-11-12 18:51
Citation	Friesen CA, Schurman JV, Abdel-Rahman SM. Present state and future challenges in pediatric abdominal pain therapeutics research: Looking beyond the forest. World J Gastrointest Pharmacol Ther 2015; 6(4): 96-104
URL	http://www.wjgnet.com/2150-5349/full/v6/i4/96.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v6.i4.96

Full Article (PDF)	WJGPT-6-96.pdf
Full Article (Word)	WJGPT-6-96.doc
Manuscript File	19328-Review.doc
Answering Reviewers	19328-Answering reviewers.pdf
Audio Core Tip	19328-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19328-Conflict-of-interest statement.pdf
Copyright License Agreement	19328-Copyright assignment.pdf
Peer-review Report	19328-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19328-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19328-Scientific misconduct check.pdf
Scientific Editor Work List	19328-Scientific editor work list .pdf