Publication Name	World Journal of Gastroenterology
Manuscript ID	19330
Country	Sweden

Received	2015-05-05 08:41
Peer-Review Started	2015-05-09 17:47
First Decision by Editorial Office Director
Return for Revision	2015-06-27 16:35
Revised	2015-07-18 05:09
Publication Fee Transferred
Second Decision by Editor	2015-09-12 22:02
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-09-14 11:32
Articles in Press	2015-09-14 11:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-25 16:50
Publish the Manuscript Online	2015-10-19 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance
Manuscript Source	Invited Manuscript
All Author List	Per Stål
Funding Agency and Grant Number	Funding Agency Grant Number Ruth and Richard Julins Foundation Stockholm County Council 20140329 Stockholm County Council 20150403 Swedish Society of Medicine (Gastroenterology Research Fund)
Corresponding Author	Per Stål, MD, PhD, Division of Gastro­enterology and Hepatology, Karolinska Institutet, Department of Digestive Diseases, Huddinge K63, Karolinska University Hospital, S-141 86 Stockholm, Sweden. per.stal@karolinska.se
Key Words	Non-alcoholic fatty liver disease; Fibrosis; Mortality; Biomarkers; Elastography
Core Tip	Non-alcoholic fatty liver disease (NAFLD) has a prevalence of 20% in the Western world. A subgroup of NAFLD patients develops inflammation and fibrosis or cirrhosis. This condition, named non-alcoholic steatohepatitis, is associated with increased mortality in liver-related and cardiovascular diseases. Advanced liver fibrosis is the histologic feature that most accurately predicts future morbidity; therefore, early detection of advanced fibrosis is crucial. Serum biomarkers, such as the NAFLD Fibrosis Score, Fib-4 Index or BARD, or non-invasive imaging techniques, such as transient elastography, may identify patients with a low risk for advanced fibrosis and minimize the need for liver biopsy.
Publish Date	2015-10-19 09:14
Citation	Stål P. Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance. World J Gastroenterol 2015; 21(39): 11077-11087
URL	http://www.wjgnet.com/1007-9327/full/v21/i39/11077.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i39.11077

Full Article (PDF)	WJG-21-11077.pdf
Full Article (Word)	WJG-21-11077.doc
Manuscript File	19330-Review.docx
Answering Reviewers	19330-Answering reviewers.pdf
Audio Core Tip	19330-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19330-Conflict-of-interest statement.pdf
Copyright License Agreement	19330-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19330-Language certificate.pdf
Peer-review Report	19330-Peer-review(s).pdf
Scientific Misconduct Check	19330-Scientific misconduct check.pdf
Scientific Editor Work List	19330-Scientific editor work list.pdf