Publication Name	World Journal of Gastroenterology
Manuscript ID	19350
Country	South Korea

Received	2015-05-06 09:31
Peer-Review Started	2015-05-11 08:59
First Decision by Editorial Office Director
Return for Revision	2015-06-27 16:41
Revised	2015-07-09 17:47
Publication Fee Transferred
Second Decision by Editor	2015-08-21 13:31
Second Decision by Editor-in-Chief	2015-08-21 15:13
Final Decision by Editorial Office Director	2015-09-02 09:02
Articles in Press	2015-09-02 09:02
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-18 09:43
Publish the Manuscript Online	2015-10-19 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Topic Highlights
Article Title	Companion diagnostics for the targeted therapy of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Changhoon Yoo and Young Soo Park
Funding Agency and Grant Number
Corresponding Author	Young Soo Park, MD, PhD, Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, South Korea. youngspark@amc.seoul.kr
Key Words	Companion diagnostics; gastric cancer; human epidermal growth factor receptor 2; fibroblast growth factor receptor; Hepatocyte growth factor receptor
Core Tip	Companion diagnostics are in vitro clinical laboratory assays designed to predict the efficacy of treatment using biomarker-based assessments. For patients with gastric cancer, immunohistochemistry for human epidermal growth factor receptor 2 (HER2) overexpression and fluorescence in situ hybridization for HER2 amplification are the only approved com-panion diagnostic devices. In this era of targeted therapy, the concurrent development of companion diagnostic techniques is critical for the success of novel therapeutics. Furthermore, the successful co-development of drug and companion diagnostics requires a thorough molecular understanding of both tumor biology and the mechanisms of drug actions.
Publish Date	2015-10-19 09:14
Citation	Yoo C, Park YS. Companion diagnostics for the targeted therapy of gastric cancer. World J Gastroenterol 2015; 21(39): 10948-10955
URL	http://www.wjgnet.com/1007-9327/full/v21/i39/10948.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i39.10948

Full Article (PDF)	WJG-21-10948.pdf
Full Article (Word)	WJG-21-10948.doc
Manuscript File	19350-Review.docx
Answering Reviewers	19350-Answering reviewers.pdf
Audio Core Tip	19350-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19350-Conflict-of-interest statement.pdf
Copyright License Agreement	19350-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19350-Language certificate.pdf
Peer-review Report	19350-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19350-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19350-Scientific misconduct check.pdf
Scientific Editor Work List	19350-Scientific editor work list.pdf