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Publication Name World Journal of Cardiology
Manuscript ID 19372
Country/Territory France
Received
2015-05-06 08:59
Peer-Review Started
2015-05-08 11:48
To Make the First Decision
2015-06-03 14:55
Return for Revision
2015-06-09 09:58
Revised
2015-06-23 23:45
Second Decision
2015-09-10 08:16
Accepted by Journal Editor-in-Chief
2015-09-11 02:30
Accepted by Company Editor-in-Chief
2015-09-18 14:07
Articles in Press
2015-09-18 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-11 17:39
Publish the Manuscript Online
2015-11-30 08:10
ISSN 1949-8462 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Review
Article Title Vascular endothelial dysfunction and pharmacological treatment
Manuscript Source Invited Manuscript
All Author List Jin Bo Su
Funding Agency and Grant Number
Corresponding Author Jin Bo Su, PhD, INSERM U955, Equipe 3, ENVA, 7 avenue du Général de Gaulle, 94700 Maisons-Alfort, France. jin-bo.su@inserm.fr
Key Words Endothelial dysfunction; Endothelium-dependent vasodilation; Endothelial nitric oxide syn­thase; Inflammation; Nitric oxide; Pharmacological treatment; Reactive nitrogen species; Reactive oxygen species; Risk factors
Core Tip The endothelium is involved in the regulation of vascular tone and permeability, coagulation and fibrinolysis, inflammatory and immunological reactions and cell growth. Cardiovascular risk factors cause vascular endothelial dysfunction through impairing endothelium-derived vasodilators, enhancing endo-thelium-derived vasoconstrictors, producing reactive oxygen species and reactive nitrogen species, activating inflammatory and immune reactions and promoting thrombosis. Among these mechanisms, a reduction in nitric oxide bioavailability plays a central role in the development and progression of endothelial dysfunction. A variety of currently used or investigational drugs exert endothelial protective effects according to specific mechanisms underlying endothelial dysfunction of the disease.
Publish Date 2015-11-30 08:10
Citation Su JB. Vascular endothelial dysfunction and pharmacological treatment. World J Cardiol 2015; 7(11): 719-741
URL http://www.wjgnet.com/1949-8462/full/v7/i11/719.htm
DOI http://dx.doi.org/10.4330/wjc.v7.i11.719
Full Article (PDF) WJC-7-719.pdf
Full Article (Word) WJC-7-719.doc
Manuscript File 19372-Review.doc
Answering Reviewers 19372-Answering reviewers.pdf
Audio Core Tip 19372-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19372-Conflict-of-interest statement.pdf
Copyright License Agreement 19372-Copyright assignment.pdf
Peer-review Report 19372-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 19372-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 19372-Scientific misconduct check.pdf
Scientific Editor Work List 19372-Scientific editor work list.pdf