Publication Name	World Journal of Cardiology
Manuscript ID	19372
Country	France

Received	2015-05-06 08:59
Peer-Review Started	2015-05-08 11:48
To Make the First Decision	2015-06-03 14:55
Return for Revision	2015-06-09 09:58
Revised	2015-06-23 23:45
Second Decision	2015-09-10 08:16
Accepted by Journal Editor-in-Chief	2015-09-11 02:30
Accepted by Executive Editor-in-Chief	2015-09-18 14:07
Articles in Press	2015-09-18 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-11 17:39
Publish the Manuscript Online	2015-11-30 08:10

ISSN	1949-8462 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Vascular endothelial dysfunction and pharmacological treatment
Manuscript Source	Invited Manuscript
All Author List	Jin Bo Su
Funding Agency and Grant Number
Corresponding Author	Jin Bo Su, PhD, INSERM U955, Equipe 3, ENVA, 7 avenue du Général de Gaulle, 94700 Maisons-Alfort, France. jin-bo.su@inserm.fr
Key Words	Endothelial dysfunction; Endothelium-dependent vasodilation; Endothelial nitric oxide syn­thase; Inflammation; Nitric oxide; Pharmacological treatment; Reactive nitrogen species; Reactive oxygen species; Risk factors
Core Tip	The endothelium is involved in the regulation of vascular tone and permeability, coagulation and fibrinolysis, inflammatory and immunological reactions and cell growth. Cardiovascular risk factors cause vascular endothelial dysfunction through impairing endothelium-derived vasodilators, enhancing endo-thelium-derived vasoconstrictors, producing reactive oxygen species and reactive nitrogen species, activating inflammatory and immune reactions and promoting thrombosis. Among these mechanisms, a reduction in nitric oxide bioavailability plays a central role in the development and progression of endothelial dysfunction. A variety of currently used or investigational drugs exert endothelial protective effects according to specific mechanisms underlying endothelial dysfunction of the disease.
Publish Date	2015-11-30 08:10
Citation	Su JB. Vascular endothelial dysfunction and pharmacological treatment. World J Cardiol 2015; 7(11): 719-741
URL	http://www.wjgnet.com/1949-8462/full/v7/i11/719.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i11.719

Full Article (PDF)	WJC-7-719.pdf
Full Article (Word)	WJC-7-719.doc
Manuscript File	19372-Review.doc
Answering Reviewers	19372-Answering reviewers.pdf
Audio Core Tip	19372-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19372-Conflict-of-interest statement.pdf
Copyright License Agreement	19372-Copyright assignment.pdf
Peer-review Report	19372-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19372-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19372-Scientific misconduct check.pdf
Scientific Editor Work List	19372-Scientific editor work list.pdf