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Articles Published Processes
1/15/2016 3:02:00 PM | Browse: 995 | Download: 1795
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Received |
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2015-05-08 16:23 |
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Peer-Review Started |
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2015-05-11 15:24 |
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To Make the First Decision |
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2015-08-31 09:15 |
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Return for Revision |
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2015-09-02 11:14 |
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Revised |
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2015-09-17 11:32 |
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Second Decision |
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2015-11-03 09:02 |
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Accepted by Journal Editor-in-Chief |
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2015-11-04 09:36 |
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Accepted by Executive Editor-in-Chief |
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2015-11-19 16:29 |
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Articles in Press |
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2015-11-19 16:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-31 08:52 |
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Publish the Manuscript Online |
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2016-01-15 14:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Group Ⅱ p21-activated kinases as therapeutic targets in gastrointestinal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yang-Guang Shao, Ke Ning and Feng Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
90813038 |
| National Natural Science Foundation of China |
31271389 |
| National Natural Science Foundation of China |
31371424 |
| National Natural Science Foundation of China |
31171360 |
| National Natural Science Foundation of China |
81230077 |
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| Corresponding Author |
Feng Li, PhD, Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, No. 77 Puhe Road, Shenbei District, Shenyang 110122, Liaoning Province, China. fli@mail.cmu.edu.cn |
| Key Words |
Group Ⅱ p21-activated kinases; Signaling pathway; Gastrointestinal cancer; PAK4 inhibitor; Drug target |
| Core Tip |
Group Ⅱ p21-activated kinases (PAKs) (PAK4, 5 and 6) are pluripotent kinases that regulate many fundamental cellular processes, including cytoskeletal organization, cell cycle regulation, cell survival and cell adhesion, and have therefore been implicated in carcinogenesis and cancer progression. Members of the group Ⅱ PAKs, particularly PAK4, have emerged as attractive targets for the development of anticancer drugs. In this review, we summarize the latest findings on the biological activities of group Ⅱ PAKs, the important roles of group Ⅱ PAKs in gastrointestinal cancer and the current status of the development of small-molecule inhibitors of PAK4 for the treatment of cancer.
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| Publish Date |
2016-01-15 14:54 |
| Citation |
Shao YG, Ning K, Li F. Group Ⅱ p21-activated kinases as therapeutic targets in gastrointestinal cancer. World J Gastroenterol 2016; 22(3): 1224-1235 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i3/1224.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i3.1224 |
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