Publication Name	World Journal of Transplantation
Manuscript ID	19468
Country	United States

Received	2015-05-09 13:25
Peer-Review Started	2015-05-11 17:39
To Make the First Decision	2015-07-26 17:26
Return for Revision	2015-07-29 17:21
Revised	2015-12-01 03:17
Second Decision	2015-12-09 17:04
Accepted by Journal Editor-in-Chief	2015-12-10 21:23
Accepted by Executive Editor-in-Chief	2015-12-15 09:07
Articles in Press	2015-12-15 09:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 21:43
Publish the Manuscript Online	2016-03-18 14:28

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Case Report
Article Title	Recurrence of lymphangioleiomyomatosis: Nine years after a bilateral lung transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Khawaja S Zaki, Zahra Aryan, Atul C Mehta, Olufemi Akindipe and Marie Budev
Funding Agency and Grant Number
Corresponding Author	Atul C Mehta, MD, FACP, FCCP, Professor of Medicine, Staff, Lerner College of Medicine, Bouncore Family Endowed Chair in Lung Transplantation, Cleveland Clinic, 2049 E 100th St, Cleveland, OH 44195, United States. mehtaa1@ccf.org
Key Words	Lymphangioleiomyomatosis; Mammalian target of rapamycin inhibitors; Lung transplantation; Sirolimus; Lung rejection
Core Tip	Lymphangioleiomyomatosis (LAM) is a rare, slowly progressive lethal lung disease characterized by proliferation of abnormal smooth muscle cells that target the lungs, causing cystic destruction and eventual respiratory failure and death. Mammalian target of rapamycin (mTOR) inhibitors such as sirolimus have shown promise in stabilization of lung function. Lung transplantation is a viable option when lung function continues to decline despite use of mTOR inhibitors. However, recurrence of LAM in transplanted lung has been reported. We describe a case of LAM recurrence in a bilateral lung transplant recipient nine years after transplantation, our therapeutic approach once recurrence was documented with review of the literature.
Publish Date	2016-03-18 14:28
Citation	Zaki KS, Aryan Z, Mehta AC, Akindipe O, Budev M. Recurrence of lymphangioleiomyomatosis: Nine years after a bilateral lung transplantation. World J Transplant 2016; 6(1): 249-254
URL	http://www.wjgnet.com/2220-3230/full/v6/i1/249.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i1.249

Full Article (PDF)	WJT-6-249.pdf
Full Article (Word)	WJT-6-249.doc
Manuscript File	19468-Review.docx
Answering Reviewers	19468-Answering reviewers.pdf
Audio Core Tip	19468-Audio core tip.wav
Conflict-of-Interest Disclosure Form	19468-Conflict-of-interest statement.pdf
Copyright License Agreement	19468-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	19468-Institutional review board statement.pdf
Peer-review Report	19468-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19468-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19468-Scientific misconduct check.pdf
Scientific Editor Work List	19468-Scientific editor work list.pdf