Publication Name	World Journal of Gastroenterology
Manuscript ID	1951
Country	China

Received	2013-01-16 09:29
Peer-Review Started	2013-01-17 08:27
First Decision by Editorial Office Director
Return for Revision	2013-04-09 20:04
Revised
Publication Fee Transferred
Second Decision by Editor	2013-06-03 11:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-06-04 08:12
Articles in Press
Edit the Manuscript by Language Editor	2013-06-08 15:46
Typeset the Manuscript	2013-07-03 11:46
Publish the Manuscript Online	2013-07-13 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Autobiography
Article Title	Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure
Manuscript Source	Invited Manuscript
All Author List	Ying-Hua Niu, Dong-Lin Yin, Hong-Li Liu, Rui-Tian Yi, Yu-Cong Yang, Hong-An Xue, Tian-Yan Chen, Shu-Lin Zhang, Shu-Mei Lin and Ying-Ren Zhao
Funding Agency and Grant Number	Funding Agency Grant Number Major National Science and Technology Projects for Infectious Diseases (11th and 12th Five Year, China) 2008ZX10002-007 Major National Science and Technology Projects for Infectious Diseases (11th and 12th Five Year, China) 2012ZX10002-007 Foundation of Shaanxi Provincial Science and Technology Plan Projects 2011K14-09-09
Corresponding Author	Dr. Ying-Ren Zhao, Professor of Medicine, Chief, Department of Infectious Diseases, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an 710061, Shaanxi Province, China. zhaoyingren@sohu.com
Key Words	Hepatitis B virus; Acute-on-chronic liver failure; Regulatory T cells; T helper 17 cells; Treg cell to Th17 cell ratio
Core Tip	In this study, the expression of circulating Treg and Th17 cells in hepatitis B virus-related acute-on-chronic liver failure (ACLF), chronic hepatitis B (CHB), and normal controls (NC) was measured using flow cytometric analysis. The percentages of circulating Treg and Th17 cells in ACLF group increased significantly compared with that in CHB group and NC group. Furthermore, the ratio of Treg to Th17 cells increased significantly upon recovery. Our study suggests that the reverting ratio of Treg to Th17 cells at the follow-up phase of ACLF could maintain the immune system at a steady state in favour of good prognosis.
Publish Date	2013-07-13 17:01
Citation	Niu YH, Yin DL, Liu HL, Yi RT, Yang YC, Xue HA, Chen TY, Zhang SL, Lin SM, Zhao YR. Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure. World J Gastroenterol 2013; 19(26): 4146-4154
URL	http://www.wjgnet.com/1007-9327/full/v19/i26/4146.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i26.4146

Full Article (PDF)	WJG-19-4146.pdf
Manuscript File	1951-Review.doc
Answering Reviewers	1951-Answering reviewers.doc
Copyright License Agreement	1951-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	伦理.jpg
Non-Native Speakers of English Editing Certificate	1951-Language certificate.pdf
Peer-review Report	1951-Peer review(s).pdf
Scientific Editor Work List	1951-Scientific editor work list.doc