Publication Name	World Journal of Gastroenterology
Manuscript ID	19553
Country	Türkiye

Received	2015-05-12 10:11
Peer-Review Started	2015-05-14 17:09
To Make the First Decision	2015-06-02 14:54
Return for Revision	2015-06-06 18:37
Revised	2015-06-23 05:35
Second Decision	2015-09-28 16:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:21
Articles in Press	2015-09-30 10:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-05 07:00
Typeset the Manuscript	2015-11-26 09:35
Publish the Manuscript Online	2015-12-09 17:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Altug Senol, Mehmet Isler, Recep Sutcu, Mete Akin, Ebru Cakir, Betul M Ceyhan and M Cem Kockar
Funding Agency and Grant Number
Corresponding Author	Mete Akin, MD, Department of Gastroenterology, Akdeniz University School of Medicine, Dumlupınar Bulvarı, Antalya 07058, Turkey. drmeteakin@hotmail.com
Key Words	Colitis; Dextran sulfate sodium; Inflammatory bowel disease; Kefir; Probiotic
Core Tip	The present study aimed to determine the pathophysiology for the preventive effect of kefir on colitis induced with dextran sulfate sodium in rats. The results show that kefir reduces the clinical disease activity index and histologic colitis scores in an experimental colitis model induced with 3% dextran sulfate sodium. The mechanisms of these beneficial effects of kefir include reductions in myeloperoxidase, tumor necrosis factor-α, and inducible nitric oxide synthase levels. Indeed, the results of this study show that the therapeutic administration of kefir may have a place in the clinical treatment of inflammatory bowel diseases.
Publish Date	2015-12-09 17:57
Citation	Senol A, Isler M, Sutcu R, Akin M, Cakir E, Ceyhan BM, Kockar MC. Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats. World J Gastroenterol 2015; 21(46): 13020-13029
URL	http://www.wjgnet.com/1007-9327/full/v21/i46/13020.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i46.13020

Full Article (PDF)	WJG-21-13020.pdf
Full Article (Word)	WJG-21-13020.doc
Manuscript File	19553-Review.doc
Answering Reviewers	19553-Answeirng reviewers.pdf
Audio Core Tip	19553-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	19553-Conflict-of-interest statement.pdf
Copyright License Agreement	19553-Copyright assigment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	19553-Institutional animal care and use committee statement.PDF
Non-Native Speakers of English Editing Certificate	19553-Language statement.pdf
Peer-review Report	19553-Peer-review(s).pdf
Scientific Misconduct Check	19553-Scientific misconduct check.pdf
Scientific Editor Work List	19553-Scientific editor work list.pdf