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Articles Published Processes
11/6/2015 6:44:00 PM | Browse: 1017 | Download: 1747
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Received |
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2015-05-13 09:32 |
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Peer-Review Started |
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2015-05-20 13:54 |
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To Make the First Decision |
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2015-06-18 15:31 |
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Return for Revision |
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2015-06-24 18:55 |
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Revised |
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2015-07-07 12:20 |
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Second Decision |
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2015-08-13 10:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-08-21 16:10 |
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Articles in Press |
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2015-08-21 16:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-20 11:58 |
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Publish the Manuscript Online |
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2015-11-06 18:44 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
In vivo analysis of intestinal permeability following hemorrhagic shock
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tom Alsaigh, Marisol Chang, Michael Richter, Rafi Mazor and Erik B Kistler |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Career Development Award |
1IK2BX001277-01A1 |
| Foundation for Anesthesia Education and Research |
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| American Society of Critical Care Anesthesiologists |
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| NIH |
GM085072-06 |
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| Corresponding Author |
Erik B Kistler, MD, PhD, Assistant Professor of Anesthesiology and Critical Care, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161-5085, United States. ekistler@ucsd.edu
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| Key Words |
Small bowel ischemia; Hemorrhagic shock; Peptides; Microcirculation; Proteolysis |
| Core Tip |
Although the concept of systemically cir-culating molecules from the bowel in response to shock is not new (e.g., bacterial “translocation”), the premise that small, proteolytically-derived molecules transit the bowel early in shock has not previously been examined. We offer evidence that proteolytically-derived peptides formed in the gut reach the systemic circulation in experimental hemorrhagic shock. The time-course and spatial disposition of low-molecular weight peptides in vivo was examined using real-time fluorescent intravital microscopy of the microcirculation and systemically as a first step towards demonstrating a pivotal role that these factors may play in affecting hemodynamic instability in early shock.
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| Publish Date |
2015-11-06 18:44 |
| Citation |
Alsaigh T, Chang M, Richter M, Mazor R, Kistler EB. In vivo analysis of intestinal permeability following hemorrhagic shock. World J Crit Care Med 2015; 4(4): 287-295 |
| URL |
http://www.wjgnet.com/2220-3141/full/v4/i4/287.htm |
| DOI |
http://dx.doi.org/10.5492/wjccm.v4.i4.287 |
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