Publication Name	World Journal of Gastroenterology
Manuscript ID	19573
Country	Brazil

Received	2015-05-13 09:04
Peer-Review Started	2015-05-15 09:36
First Decision by Editorial Office Director
Return for Revision	2015-10-21 14:02
Revised	2015-11-04 00:09
Publication Fee Transferred
Second Decision by Editor	2015-11-09 16:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-11-24 17:15
Articles in Press	2015-11-24 17:15
Edit the Manuscript by Language Editor	2015-12-21 12:03
Typeset the Manuscript	2016-01-15 15:27
Publish the Manuscript Online	2016-01-23 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-/ribavirin therapy
Manuscript Source	Invited Manuscript
All Author List	Gerson Dierley Keppeke, S John Calise, Edward KL Chan and Luis Eduardo C Andrade
Funding Agency and Grant Number	Funding Agency Grant Number Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships process 9028-11-0 (to Andrade LEC and Keppeke GD) Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships process 305064/2011-8 (to Andrade LEC and Keppeke GD) Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships process 232711/2014-3 (to Andrade LEC and Keppeke GD) Sao Paulo Government agency Sao Paulo State Research Foundation with process 2011/12448-0 (to Andrade LEC and Keppeke GD)
Corresponding Author	Luis Eduardo C Andrade, Professor, Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 740, São Paulo, SP 04023-062, Brazil. luis.andrade@unifesp.br
Key Words	Rods and rings; Autoantibodies; Hepatitis C; Ribavirin; Interferon-α
Core Tip	Between 20% and 40% of hepatitis C virus patients treated with interferon-α and ribavirin develop autoantibodies showing a peculiar antinuclear antibodies pattern characterized as rods and rings (RR) structures. In those patients, the first appearance of anti-RR autoantibodies occurs around the sixth month of treatment and reaches a plateau around the twelfth month. The main target of anti-RR autoantibodies is the inosine-5’-monophosphate dehydrogenase 2 (IMPDH2) enzyme, critical in de novo GTP biosynthesis. In cell culture, IMPDH2 inhibition by ribavirin promotes its aggregation into RR structures. These observations led to the hypothesis that anti-RR autoantibody production represents a human model of immunologic tolerance breakdown that allows us to explore interesting aspects of the humoral autoimmune response from the beginning of the putative triggering event.
Publish Date	2016-01-23 17:08
Citation	Keppeke GD, Calise SJ, Chan EKL, Andrade LEC. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-/ribavirin therapy. World J Gastroenterol 2016; 22(6): 1966-1974
URL	http://www.wjgnet.com/1007-9327/full/v22/i6/1966.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i6.1966

Full Article (PDF)	WJG-22-1966.pdf
Full Article (Word)	WJG-22-1966.doc
Manuscript File	19573-Review.docx
Answering Reviewers	19573-Answering reviewers.pdf
Audio Core Tip	19573-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19573-Conflict-of-interest statement.pdf
Copyright License Agreement	19573-Copyright assignment.pdf
Peer-review Report	19573-Peer-review(s).pdf
Scientific Misconduct Check	19573-Scientific misconduct check.pdf
Scientific Editor Work List	19573-Scientific editor work list.pdf