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Articles Published Processes
1/23/2016 5:08:00 PM | Browse: 1469 | Download: 1893
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Received |
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2015-05-13 09:04 |
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Peer-Review Started |
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2015-05-15 09:36 |
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To Make the First Decision |
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2015-10-14 16:57 |
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Return for Revision |
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2015-10-21 14:02 |
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Revised |
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2015-11-04 00:09 |
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Second Decision |
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2015-11-09 16:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-11-24 17:15 |
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Articles in Press |
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2015-11-24 17:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-12-21 12:03 |
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Typeset the Manuscript |
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2016-01-15 15:27 |
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Publish the Manuscript Online |
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2016-01-23 17:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-/ribavirin therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gerson Dierley Keppeke, S John Calise, Edward KL Chan and Luis Eduardo C Andrade |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships process |
9028-11-0 (to Andrade LEC and Keppeke GD) |
| Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships process |
305064/2011-8 (to Andrade LEC and Keppeke GD) |
| Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships process |
232711/2014-3 (to Andrade LEC and Keppeke GD) |
| Sao Paulo Government agency Sao Paulo State Research Foundation with process |
2011/12448-0 (to Andrade LEC and Keppeke GD) |
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| Corresponding Author |
Luis Eduardo C Andrade, Professor, Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 740, São Paulo, SP 04023-062, Brazil. luis.andrade@unifesp.br |
| Key Words |
Rods and rings; Autoantibodies; Hepatitis C; Ribavirin; Interferon-α |
| Core Tip |
Between 20% and 40% of hepatitis C virus patients treated with interferon-α and ribavirin develop autoantibodies showing a peculiar antinuclear antibodies pattern characterized as rods and rings (RR) structures. In those patients, the first appearance of anti-RR autoantibodies occurs around the sixth month of treatment and reaches a plateau around the twelfth month. The main target of anti-RR autoantibodies is the inosine-5’-monophosphate dehydrogenase 2 (IMPDH2) enzyme, critical in de novo GTP biosynthesis. In cell culture, IMPDH2 inhibition by ribavirin promotes its aggregation into RR structures. These observations led to the hypothesis that anti-RR autoantibody production represents a human model of immunologic tolerance breakdown that allows us to explore interesting aspects of the humoral autoimmune response from the beginning of the putative triggering event. |
| Publish Date |
2016-01-23 17:08 |
| Citation |
Keppeke GD, Calise SJ, Chan EKL, Andrade LEC. Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-/ribavirin therapy. World J Gastroenterol 2016; 22(6): 1966-1974 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i6/1966.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i6.1966 |
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