Publication Name	World Journal of Hepatology
Manuscript ID	19580
Country	Italy

Received	2015-05-13 08:41
Peer-Review Started	2015-05-15 14:23
To Make the First Decision	2015-06-23 15:01
Return for Revision	2015-06-26 17:18
Revised	2015-07-08 17:55
Second Decision	2015-09-28 16:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-09 11:08
Articles in Press	2015-10-09 11:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-16 16:03
Publish the Manuscript Online	2015-10-30 11:57

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact
Manuscript Source	Invited Manuscript
All Author List	Caterina Sagnelli, Salvatore Martini, Mariantonietta Pisaturo, Giuseppe Pasquale, Margherita Macera, Rosa Zampino, Nicola Coppola and Evangelista Sagnelli
Funding Agency and Grant Number
Corresponding Author	Evangelista Sagnelli, Professor, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via L. Armanni 5, 80131 Naples, Italy. evangelistasagnelli@libero.it
Key Words	Human immunodeficiency virus/hepatitis C virus coinfection; Liver fibrosis; Liver biopsy; Fibroscan; Liver ultrasonography
Core Tip	The extent of liver fibrosis is a marker of disease progression influencing the clinical and therapeutic decisions to be made for human immuno?deficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. The international guidelines suggest anti-HCV therapy for HIV/HCV-coinfected patients with histological fibrosis score ≥ 2 in the Metavir scoring system since they have an increased risk of liver failure. Due to the high clinical impact of liver fibrosis and of the well-known limitations of liver biopsy, surrogate, non-invasive technologies have been researched. The pros and cons of liver biopsy and surrogate technologies in detecting liver fibrosis in HIV/HCV-coinfected patients will be discussed in this review article.
Publish Date	2015-10-30 11:57
Citation	Sagnelli C, Martini S, Pisaturo M, Pasquale G, Macera M, Zampino R, Coppola N, Sagnelli E. Liver fibrosis in human immuno¬deficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact. World J Hepatol 2015; 7(24): 2510-2521
URL	http://www.wjgnet.com/1948-5182/full/v7/i24/2510.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i24.2510

Full Article (PDF)	WJH-7-2510.pdf
Full Article (Word)	WJH-7-2510.doc
Manuscript File	19580-Review.doc
Answering Reviewers	19580-Answering reviewers.pdf
Audio Core Tip	19580-Audio core tip.m4a
Copyright License Agreement	19580-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19580-Language certificate.pdf
Peer-review Report	19580-Peer-review(s).pdf
Scientific Misconduct Check	19580-Scientific misconduct check.pdf
Scientific Editor Work List	19580-Scientific editor work list.pdf