Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	19612
Country	Romania

Received	2015-05-14 09:01
Peer-Review Started	2015-05-15 16:10
To Make the First Decision	2015-06-02 14:56
Return for Revision	2015-06-06 18:59
Revised	2015-06-20 15:14
Second Decision	2015-09-28 16:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-09 11:13
Articles in Press	2015-10-09 11:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-26 12:02
Publish the Manuscript Online	2015-11-17 08:51

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Autophagy in colorectal cancer: An important switch from physiology to pathology
Manuscript Source	Invited Manuscript
All Author List	Florin Burada, Elena Raluca Nicoli, Marius Eugen Ciurea, Daniel Constantin Uscatu, Mihai Ioana and Dan Ionut Gheonea
Funding Agency and Grant Number	Funding Agency Grant Number European Social Found, Human Resources Development Operational Programme 2007-2013 POSDRU/159/1.5/S/133377 (to Burada F)
Corresponding Author	Florin Burada, MD, PhD, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 1 Mai 66, 200638 Craiova, Romania. buradaflorin@gmail.com
Key Words	Colorectal cancer; Autophagy; Gene; Protein; Carcinogenesis
Core Tip	This review describes the role of autophagy in cancer, focusing on the involvement of autophagy in colorectal cancer (CRC). Initially, we describe the steps and components of autophagy, and we then further highlight the dual role of autophagy in cancer, where it can potentially act as both a promoter and an inhibitor during the transformation from normal to malignant cell. In particular, we emphasize the major autophagy genes involved in CRC pathogenesis along with autophagy-modulating agents and their modes of action in the context of CRC therapy.
Publish Date	2015-11-17 08:51
Citation	Burada F, Nicoli ER, Ciurea ME, Uscatu DC, Ioana M, Gheonea DI. Autophagy in colorectal cancer: An important switch from physiology to pathology. World J Gastrointest Oncol 2015; 7(11): 271-284
URL	http://www.wjgnet.com/1948-5204/full/v7/i11/271.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i11.271

Full Article (PDF)	WJGO-7-271.pdf
Full Article (Word)	WJGO-7-271.doc
Manuscript File	19612-Review.doc
Answering Reviewers	19612-Answering reviewers.pdf
Audio Core Tip	19612-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19612-Conflict-of-interest statement.pdf
Copyright License Agreement	19612-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19612-Language certificate.pdf
Supplementary Material	19612-Google Scholar and CrossCheck (2 variants).doc
Peer-review Report	19612-Peer-review(s).pdf
Scientific Misconduct Check	19612-Scientific misconduct check.pdf
Scientific Editor Work List	19612-Scientific editor work list.pdf