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Articles Published Processes
3/2/2016 1:35:00 PM | Browse: 1199 | Download: 1965
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Received |
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2015-05-14 19:31 |
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Peer-Review Started |
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2015-05-15 17:21 |
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To Make the First Decision |
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2015-06-19 18:04 |
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Return for Revision |
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2015-06-20 20:17 |
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Revised |
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2015-08-04 18:45 |
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Second Decision |
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2015-10-23 16:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-11-09 17:01 |
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Articles in Press |
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2015-11-09 17:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-01-04 09:23 |
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Typeset the Manuscript |
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2016-02-16 11:34 |
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Publish the Manuscript Online |
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2016-03-02 13:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
New role and molecular mechanism of Gadd45a in hepatic fibrosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang Hong, Qing-Feng Sun, Ting-Yan Xu, Yang-He Wu, Hui Zhang, Rong-Quan Fu, Fu-Jing Cai, Qing-Qing Zhou, Ke Zhou, Qing-Wei Du, Dong Zhang, Shuang Xu and Ji-Guang Ding |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medicine and Health Research Programs of Zhejiang Province |
2013KYB252 |
| Science Foundation of the Science and Technology Commission of Ruian City |
201302012 |
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| Corresponding Author |
Ji-Guang Ding, MD, Department of Infectious Diseases, the Third Affiliated Hospital to Wenzhou Medical University, 108 Wansong Road, Wenzhou 325200, Zhejiang Province, China. djg5011@163.com
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| Key Words |
Antioxidant; Gadd45a; Hepatic fibrosis; Hepatic stellate cells; Transforming growth factor-β/Smad signaling |
| Core Tip |
The data in this paper provide evidence that Gadd45a may exert a protective effect against hepatic fibrosis induced by CCl4, via the inhibition of canonical transforming growth factor-β/Smad signaling and fibrogenic gene expression. We also propose a molecular basis for the antioxidant potential of Gadd45a in the hepatic fibrosis process. Although clinical methods for the direct targeting of hepatic stellate cells remain under development, our study provides an important advance in the understanding of the biologic functions of Gadd45a and a potential target for the treatment of hepatic fibrosis.
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| Publish Date |
2016-03-02 13:35 |
| Citation |
Hong L, Sun QF, Xu TY, Wu YH, Zhang H, Fu RQ, Cai FJ, Zhou QQ, Zhou K, Du QW, Zhang D, Xu S, Ding JG. New role and molecular mechanism of Gadd45a in hepatic fibrosis. World J Gastroenterol 2016; 22(9): 2779-2788 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i9/2779.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i9.2779 |
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