Publication Name	World Journal of Gastroenterology
Manuscript ID	19663
Country	Japan

Received	2015-05-16 14:52
Peer-Review Started	2015-05-19 11:08
To Make the First Decision	2015-07-14 11:45
Return for Revision	2015-07-24 15:59
Revised	2015-07-27 19:19
Second Decision	2015-10-10 18:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-10-13 18:06
Articles in Press	2015-10-13 18:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-05 05:47
Typeset the Manuscript	2015-12-02 15:08
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Pei-Pei Song, Ju-Feng Xia, Yoshinori Inagaki, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Norihiro Kokudo and Wei Tang
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Science, Sports, and Culture of Japan
Corresponding Author	Wei Tang, MD, PhD, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
Key Words	Hepatocellular carcinoma; Biomarker; Guideline; Surveillance; Diagnosis; Prognosis
Core Tip	Hepatocellular carcinoma (HCC) is a major global health problem due to the high prevalence of the risk factors hepatitis B virus and hepatitis C virus infection. Thus, a good surveillance program and diagnostic strategy for the early detection of HCC should be available. This review summarizes the controversies regarding and perspectives on clinical utility of biomarkers in HCC, especially the current role of alpha-fetoprotein and des-γ-carboxyprothrombin. In addition, research frontiers and prospects for novel biomarkers to evaluate the prognosis for HCC and to facilitate post-treatment monitoring are reviewed.
Publish Date	2015-12-31 13:27
Citation	Song PP, Xia JF, Inagaki Y, Hasegawa K, Sakamoto Y, Kokudo N, Tang W. Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma. World J Gastroenterol 2016; 22(1): 262-274
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/262.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.262

Full Article (PDF)	WJG-22-262.pdf
Full Article (Word)	WJG-22-262.doc
Manuscript File	19663-Review.docx
Answering Reviewers	19663-Answering reviewers.pdf
Audio Core Tip	19663-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	19663-Conflict-of-interest statement.pdf
Copyright License Agreement	19663-Copyright assignment.pdf
Peer-review Report	19663-Peer-review(s).pdf
Scientific Misconduct Check	19663-Scientific misconduct check.pdf
Scientific Editor Work List	19663-Scientific editor work list.pdf