Publication Name	World Journal of Gastroenterology
Manuscript ID	19672
Country	Chile

Received	2015-05-16 14:39
Peer-Review Started	2015-05-20 10:30
To Make the First Decision	2015-07-14 11:46
Return for Revision	2015-07-24 16:13
Revised	2015-08-06 12:16
Second Decision	2015-10-10 18:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 18:25
Articles in Press	2015-10-13 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-05 05:26
Typeset the Manuscript	2015-12-03 09:44
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
Manuscript Source	Invited Manuscript
All Author List	Fernando Ezquer, Flavia Bruna, Sebastián Calligaris, Paulette Conget and Marcelo Ezquer
Funding Agency and Grant Number
Corresponding Author	Dr. Marcelo Ezquer, Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Av. Las Condes 12438, Santiago 7710162, Chile. mezquer@udd.cl
Key Words	Alcoholic liver disease; Cellular therapy; Alcoholic steatohepatitis; Hepatic function recovery; Mesenchymal stem cells
Core Tip	Chronic alcohol consumption is a major cause of liver disease. Stem cells, in particular multipotent mesenchymal stromal cells (MSCs), have been envi-sioned as a promising tool for the development of therapeutic strategies to treat alcoholic liver diseases (ALD). The advantages of MSC include the regulation of exacerbated inflammatory process, their differentiation into hepatocytes, the production of trophic factors that prevent the apoptosis of parenchymal cells, and the induction of the proliferation of endogenous progenitors. Here, we revise the pathophysiology of ALD to identify therapeutic targets for MSCs. Also, we discuss the rationale to propose an MSC-based therapy to treat ALD.
Publish Date	2015-12-31 13:27
Citation	Ezquer F, Bruna F, Calligaris S, Conget P, Ezquer M. Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World J Gastroenterol 2016; 22(1): 24-36
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/24.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.24

Full Article (PDF)	WJG-22-24.pdf
Full Article (Word)	WJG-22-24.doc
Manuscript File	19672-Review.docx
Answering Reviewers	19672-Answering reviewers.pdf
Audio Core Tip	19672-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19672-Conflict-of-interest statement.pdf
Copyright License Agreement	19672-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19672-Language certificate.pdf
Peer-review Report	19672-Peer-review(s).pdf
Scientific Misconduct Check	19672-Scientific misconduct check.pdf
Scientific Editor Work List	19672-Scientific editor work list.pdf