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12/31/2015 1:27:00 PM | Browse: 1065 | Download: 1462
Publication Name World Journal of Gastroenterology
Manuscript ID 19672
Country/Territory Chile
Received
2015-05-16 14:39
Peer-Review Started
2015-05-20 10:30
To Make the First Decision
2015-07-14 11:46
Return for Revision
2015-07-24 16:13
Revised
2015-08-06 12:16
Second Decision
2015-10-10 18:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-10-13 18:25
Articles in Press
2015-10-13 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-11-05 05:26
Typeset the Manuscript
2015-12-03 09:44
Publish the Manuscript Online
2015-12-31 13:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
Manuscript Source Invited Manuscript
All Author List Fernando Ezquer, Flavia Bruna, Sebastián Calligaris, Paulette Conget and Marcelo Ezquer
Funding Agency and Grant Number
Corresponding Author Dr. Marcelo Ezquer, Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Av. Las Condes 12438, Santiago 7710162, Chile. mezquer@udd.cl
Key Words Alcoholic liver disease; Cellular therapy; Alcoholic steatohepatitis; Hepatic function recovery; Mesenchymal stem cells
Core Tip Chronic alcohol consumption is a major cause of liver disease. Stem cells, in particular multipotent mesenchymal stromal cells (MSCs), have been envi-sioned as a promising tool for the development of therapeutic strategies to treat alcoholic liver diseases (ALD). The advantages of MSC include the regulation of exacerbated inflammatory process, their differentiation into hepatocytes, the production of trophic factors that prevent the apoptosis of parenchymal cells, and the induction of the proliferation of endogenous progenitors. Here, we revise the pathophysiology of ALD to identify therapeutic targets for MSCs. Also, we discuss the rationale to propose an MSC-based therapy to treat ALD.
Publish Date 2015-12-31 13:27
Citation Ezquer F, Bruna F, Calligaris S, Conget P, Ezquer M. Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World J Gastroenterol 2016; 22(1): 24-36
URL http://www.wjgnet.com/1007-9327/full/v22/i1/24.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i1.24
Full Article (PDF) WJG-22-24.pdf
Full Article (Word) WJG-22-24.doc
Manuscript File 19672-Review.docx
Answering Reviewers 19672-Answering reviewers.pdf
Audio Core Tip 19672-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19672-Conflict-of-interest statement.pdf
Copyright License Agreement 19672-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 19672-Language certificate.pdf
Peer-review Report 19672-Peer-review(s).pdf
Scientific Misconduct Check 19672-Scientific misconduct check.pdf
Scientific Editor Work List 19672-Scientific editor work list.pdf