Publication Name	World Journal of Psychiatry
Manuscript ID	19706
Country	Italy

Received	2015-05-18 08:24
Peer-Review Started	2015-05-19 14:43
To Make the First Decision	2015-07-02 13:30
Return for Revision	2015-07-10 14:30
Revised	2015-07-28 21:55
Second Decision	2015-08-13 10:15
Accepted by Journal Editor-in-Chief	2015-08-13 20:07
Accepted by Executive Editor-in-Chief	2015-08-21 16:16
Articles in Press	2015-08-21 16:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-16 16:22
Publish the Manuscript Online	2015-09-27 17:16

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Systematic Reviews
Article Title	Pharmacologic approaches to treatment resistant depression: Evidences and personal experience
Manuscript Source	Invited Manuscript
All Author List	Antonio Tundo, Rocco de Filippis and Luca Proietti
Funding Agency and Grant Number
Corresponding Author	Antonio Tundo, MD, Istituto di Psicopa­tologia, Private Outpatients Clinic, via Girolamo da Carpi 1, 00196 Roma, Italy. tundo@istitutodipsicopatologia.it
Key Words	Treatment resistant depression; Combination; Augmentation; Switching; Non responder depression; Partial response depression; Major depressive disorder; Antidepressants; Second generation antipsychotics; Dopamine-agonists
Core Tip	According to the available evidences and our personal experience we suggest to treat patients non-responders: to one selective serotonin reuptake inhibitors antidepressants (SSRI), buproprion or mirtaza-pine trial by switching to venlafaxine; to one venlafaxine trial by switching to tricyclic antidepressants (TCA) or, if TCA are not tolerated, by combining mirtaza-pine with SSRI or venlafaxine; to two or more adequate antidepressant (AD) trials (including TCA if tolerate) by AD augmentation with lithium (mainly in patients with bipolar depression or suicidality), second generation antipsychotics (SGAs) (mostly aripiprazole) or dopamine-agonists (mostly pramipexole); to combination and augmentation strategies and elettroconvulsive therapy (ECT), if workable, by combination plus augmentation strategy. Combining the available evidences and our personal experience we suggest: for non-responders to one SSRI (buproprion or mirtazapine) trial switching to venlafaxine for non-responders to one venlafaxine trial switching to TCA, if TCA are not tolerated, combining mirtazapine with SSRI or venlafaxine. For non-responders to two or more AD trials (including TCA if tolerate) we suggest AD augmentation with lithium (bipolar depression or suicidality), SGAs (aripiprazole) or dopamine-agonists (pramipexole) for non-responders to combination and augmentation strategies and ECT, if possible, we suggest a combination plus augmentation strategy.
Publish Date	2015-09-27 17:16
Citation	Tundo A, de Filippis R, Proietti L. Pharmacologic approaches to treatment resistant depression: Evidences and personal experience. World J Psychiatr 2015; 5(3): 330-341
URL	http://www.wjgnet.com/2220-3206/full/v5/i3/330.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i3.330

Full Article (PDF)	WJP-5-330.pdf
Full Article (Word)	WJP-5-330.doc
Manuscript File	19706-Review.docx
Answering Reviewers	19706-Answering reviewers.pdf
Audio Core Tip	19706-Audio core tip.m4a
Biostatistics Review Certificate	19706-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19706-Conflict-of-interest statement.pdf
Copyright License Agreement	19706-Copyright assignment.pdf
Peer-review Report	19706-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19706-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19706-Scientific misconduct check.pdf
Scientific Editor Work List	19706-Scientific editor work list.pdf