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Articles Published Processes
12/31/2015 1:27:00 PM | Browse: 1181 | Download: 1743
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Received |
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2015-05-19 09:11 |
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Peer-Review Started |
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2015-05-20 08:01 |
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To Make the First Decision |
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2015-08-26 10:04 |
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Return for Revision |
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2015-08-27 11:03 |
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Revised |
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2015-11-11 01:17 |
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Second Decision |
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2015-12-01 10:37 |
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Accepted by Journal Editor-in-Chief |
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2015-12-02 20:07 |
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Accepted by Executive Editor-in-Chief |
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2015-12-14 15:54 |
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Articles in Press |
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2015-12-14 15:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-21 10:10 |
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Publish the Manuscript Online |
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2015-12-31 13:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Topic Highlights |
| Article Title |
Prophylactic managements of hepatitis B viral infection in liver transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Takashi Onoe, Hiroyuki Tahara, Yuka Tanaka and Hideki Ohdan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japanese Ministry of Health, Labour and Welfare |
for the Research of Hepatitis and BSE |
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| Corresponding Author |
Dr. Takashi Onoe, MD, PhD, Head, Division of Applied Immunobiology, Institute for Clinical Research, National Hospital Organization, Kure Medical Center/Chugoku Cancer Center, 3-1 Aoyama-cho, Kure, Hiroshima 737-0023, Japan. tonoemd@gmail.com
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| Key Words |
Liver transplantation; Hepatitis B infection; prophylaxis; nucleos(t)ide analogue; anti-hepatitis B immunoglobulin |
| Core Tip |
Combination therapy consisting of high-dose hepatitis B immunoglobulin (HBIG) and lamivudine has been the standard prophylaxis for hepatitis B virus recurrence after liver transplantation. Currently, after development of more potent high genetic barrier nucleos(t)ide analogues (hgbNAs), such as entecavir and tenofovir disoproxil fumarate, combination therapy using low-dose HBIG and hgbNA is considered as the most efficacious and cost-effective prophylaxis. In addition, monotherapy with hgbNAs and withdrawal of HBIG following combination therapy of HBIG and hgbNAs could be promising approaches, especially for low-risk patients and those receiving grafts from hepatitis B core antibody-positive donors. This review discusses those approaches including other challenging therapeutic options.
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| Publish Date |
2015-12-31 13:27 |
| Citation |
Onoe T, Tahara H, Tanaka Y, Ohdan H. Prophylactic managements of hepatitis B viral infection in liver transplantation. World J Gastroenterol 2016; 22(1): 165-175 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i1/165.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i1.165 |
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