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Articles Published Processes
3/28/2016 8:56:00 AM | Browse: 1141 | Download: 1891
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Received |
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2015-05-18 15:19 |
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Peer-Review Started |
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2015-05-20 08:36 |
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To Make the First Decision |
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2015-10-08 15:54 |
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Return for Revision |
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2015-10-17 18:26 |
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Revised |
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2015-10-30 08:32 |
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Second Decision |
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2016-01-25 14:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-02-16 09:02 |
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Articles in Press |
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2016-02-16 09:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-24 17:55 |
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Publish the Manuscript Online |
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2016-03-28 08:57 |
| ISSN |
2219-2824 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Intracellular localisation of Mycobacterium marinum in mast cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sadiyo Siad, Simon Byrne, Galina Mukamolova and Cordula Stover |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Faculty for the Future Fellowship grant by the Schlumberger Foundation |
(to Siad S) |
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| Corresponding Author |
Dr. med. Cordula Stover, PhD, Senior Lecturer in Immunology, Department of Infection, Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom. cms13@le.ac.uk
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| Key Words |
Mast cells; Mycobacterium marinum; Microscopy; Infection; Degranulation |
| Core Tip |
Mycobacterium marinum (M. marinum) is easily culturable and shows promise as a model to understand in mammalian cells the pathogenicity of M. tuberculosis. We used M. marinum to study uptake and elimination of M. marinum by mast cells, being abundant immune effector cells. A range of imaging techniques was used to unequivocally show the intracellular presence of M. marinum. Mast cells did not control the replication of M. marinum but reacted in a pro-inflammatory way. This is consistent with mast cells being orchestrators of inflammation. In summary, we clearly show that M. marinum can infect mast cells, survive and replicate within.
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| Publish Date |
2016-03-28 08:57 |
| Citation |
Siad S, Byrne S, Mukamolova G, Stover C. Intracellular localisation of Mycobacterium marinum in mast cells. World J Immunol 2016; 6(1): 83-95 |
| URL |
http://www.wjgnet.com/2219-2824/full/v6/i1/83.htm |
| DOI |
http://dx.doi.org/10.5411/wji.v6.i1.83 |
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