Publication Name	World Journal of Gastroenterology
Manuscript ID	19720
Country	United States

Received	2015-05-18 15:43
Peer-Review Started	2015-05-20 08:50
To Make the First Decision	2015-07-13 15:19
Return for Revision	2015-07-17 16:53
Revised	2015-08-06 00:00
Second Decision	2015-09-13 22:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-15 13:47
Articles in Press	2015-09-15 13:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 17:05
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Treatment-related gastrointestinal toxicities and advanced colorectal or pancreatic cancer: A critical update
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Aprile, Karim Rihawi, Elisa De Carlo and Stephen T Sonis
Funding Agency and Grant Number
Corresponding Author	Stephen T Sonis, DMD, DMSc, Divisions of Oral Medicine, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, United States. ssonis@partners.org
Key Words	Gastrointestinal toxicities; Oral mucositis; Diarrhea; Colorectal cancer; Pancreatic cancer
Core Tip	Although extremely frequent, treatment-related gastrointestinal toxicities in patients with advanced colorectal cancer and pancreatic cancer are often underreported. As such, it is difficult to establish to what extent such toxicities affect both patient quality of life and cancer care costs. In our work we describe the main gastrointestinal toxicities as well as their pathophysiology and grading scales. Finally, based on the results of the main randomized clinical trials, we provide a critical update on their incidence with both chemotherapeutic agents and novel targeted drugs.
Publish Date	2015-11-03 17:31
Citation	Aprile G, Rihawi K, De Carlo E, Sonis ST. Treatment-related gastrointestinal toxicities and advanced colorectal or pancreatic cancer: A critical update. World J Gastroenterol 2015; 21(41): 11793-11803
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11793.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11793

Full Article (PDF)	WJG-21-11793.pdf
Full Article (Word)	WJG-21-11793.doc
Manuscript File	19720-Review.doc
Answering Reviewers	19720-Answering reviewers.pdf
Audio Core Tip	19720-Audio core tip.wav
Conflict-of-Interest Disclosure Form	19720-Conflict-of-interest statement.pdf
Copyright License Agreement	19720-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20150518154234.pdf
Peer-review Report	19720-Peer-review(s).pdf
Scientific Misconduct Check	19720-Scientific misconduct check.pdf
Scientific Editor Work List	19720-Scientific editor work list.pdf