Publication Name	World Journal of Gastroenterology
Manuscript ID	19724
Country	Taiwan

Received	2015-05-19 08:54
Peer-Review Started	2015-05-20 09:26
To Make the First Decision	2015-09-09 17:32
Return for Revision	2015-09-15 11:27
Revised	2015-10-14 21:02
Second Decision	2015-11-11 16:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-24 16:50
Articles in Press	2015-11-24 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-09 07:42
Typeset the Manuscript	2015-12-20 20:50
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes
Manuscript Source	Invited Manuscript
All Author List	Yuan-Chi Teng, Zhao-Qing Shen, Cheng-Heng Kao and Ting-Fen Tsai
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology (MOST) in Taiwan NSC99-2628-B-010-001-MY3 Ministry of Science and Technology (MOST) in Taiwan MOST 103-2321-B-010-003 Ministry of Science and Technology (MOST) in Taiwan MOST 103-2633-H-010-001 Ministry of Science and Technology (MOST) in Taiwan MOST 103-2633-B-400-002 Ministry of Science and Technology (MOST) in Taiwan MOST104-3011-B-010-001 Ministry of Education, Aim for the Top University Plan
Corresponding Author	Ting-Fen Tsai, PhD, Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, 155 Li-Nong Street, Sec. 2, Beitou, Taipei 112, Taiwan. tftsai@ym.edu.tw
Key Words	Hepatocellular carcinoma; Mouse models; Hepatitis B virus; Haploinsufficiency; Tumor suppressor genes
Core Tip	Hepatitis B virus (HBV) viral products, in particular the oncogenic HBV X protein, and mutations of tumor suppressor genes (TSGs) are the driving force of hepatocellular carcinoma (HCC). Inactivation of a recessive TSG requires mutations in both alleles and fits the “two-hit” model. However, haploinsufficiency occurs when one allele is insufficient to confer the full functionality of a TSG; the gene’s effect can be partial or complete depending on tissue type, genetic modifiers/background, and environmental factors. Mouse models play a pivotal role in demonstrating the oncogenic effects of viral products and in establishing the dose-dependency and quantitative differences when analyzing a TSG involved in HCC.
Publish Date	2015-12-31 13:27
Citation	Teng YC, Shen ZQ, Kao CH, Tsai TF. Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes. World J Gastroenterol 2016; 22(1): 300-325
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/300.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.300

Full Article (PDF)	WJG-22-300.pdf
Full Article (Word)	WJG-22-300.doc
Manuscript File	19724-Review.docx
Answering Reviewers	19724-Answering reviewer.pdf
Audio Core Tip	19724-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19724-Confilct-of-interest statement.pdf
Copyright License Agreement	19724-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19724-Language certificate.pdf
Peer-review Report	19724-Peer-review(s).pdf
Scientific Misconduct Check	19724-Scientific misconduct check.pdf
Scientific Editor Work List	19724-Scientific editor work list.pdf