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Articles Published Processes
1/6/2016 4:13:00 PM | Browse: 1007 | Download: 1408
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Received |
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2015-05-20 08:56 |
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Peer-Review Started |
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2015-05-20 19:50 |
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To Make the First Decision |
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2015-08-26 10:04 |
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Return for Revision |
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2015-08-27 11:57 |
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Revised |
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2015-09-09 06:06 |
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Second Decision |
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2015-11-09 16:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-11-24 17:17 |
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Articles in Press |
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2015-11-24 17:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-18 16:12 |
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Publish the Manuscript Online |
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2016-01-06 16:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Mouse models for the discovery of colorectal cancer driver genes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christopher R Clark and Timothy K Starr |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 3M Science and Technology Fellowship Award |
(to Clark CR) |
| National Cancer Institute of the National Institutes of Health |
5R00CA151672-03 (to Star TK) |
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| Corresponding Author |
Timothy K Starr, PhD, Assistant Professor, Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, United States. star0044@umn.edu |
| Key Words |
Mouse models; Colorectal cancer; Cancer genes; Insertional mutagenesis; Transposable elements |
| Core Tip |
Successful implementation of targeted therapy will require a much more sophisticated understanding of colorectal cancer genetics, including the ability to discern “driver” mutations from the more common “passenger” mutations. Interpreting causality from large human genomic datasets will benefit from data produced by animal models and will expedite clinical trials using targeted therapies. This review describes the benefits and limitations of both traditional and new mouse models that are being used to discover and define colorectal cancer driver genes. |
| Publish Date |
2016-01-06 16:13 |
| Citation |
Clark CR, Starr TK. Mouse models for the discovery of colorectal cancer driver genes. World J Gastroenterol 2016; 22(2): 815-822 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i2/815.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i2.815 |
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