Publication Name	World Journal of Cardiology
Manuscript ID	19779
Country	Taiwan

Received	2015-05-21 09:03
Peer-Review Started	2015-05-21 14:56
To Make the First Decision	2015-08-16 16:54
Return for Revision	2015-08-19 17:32
Revised	2015-08-30 15:55
Second Decision	2015-09-14 10:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-28 17:22
Articles in Press	2015-09-28 17:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-11 17:40
Publish the Manuscript Online	2015-11-30 08:10

ISSN	1949-8462 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Therapeutic modification of arterial stiffness: An update and comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Ching-Fen Wu, Pang-Yen Liu, Tsung-Jui Wu, Yuan Hung, Shih-Ping Yang and Gen-Min Lin
Funding Agency and Grant Number
Corresponding Author	Gen-Min Lin, MD, MPH, Department of Medicine, Hualien-Armed Forces General Hospital, No. 163, Jiali Rd. Xincheng Township, Hualien 97144, Taiwan. farmer507@yahoo.com.tw
Key Words	Arterial stiffness; Cardio-ankle vascular index; Pulse-wave velocity; Renin-angiotensin-aldo­sterone system antagonist
Core Tip	Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dysli-pidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk.
Publish Date	2015-11-30 08:10
Citation	Wu CF, Liu PY, Wu TJ, Hung Y, Yang SP, Lin GM. Therapeutic modification of arterial stiffness: An update and comprehensive review. World J Cardiol 2015; 7(11): 742-753
URL	http://www.wjgnet.com/1949-8462/full/v7/i11/742.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i11.742

Full Article (PDF)	WJC-7-742.pdf
Full Article (Word)	WJC-7-742.doc
Manuscript File	19779-Review.docx
Answering Reviewers	19779-Answering reviewers.pdf
Audio Core Tip	19779-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19779-Conflict-of-interest statement.pdf
Copyright License Agreement	19779-Copyright assignment.pdf
Peer-review Report	19779-Peer-review(s).pdf
Scientific Misconduct Check	19779-Scientific misconduct check.pdf
Scientific Editor Work List	19779-Scientific editor work list.pdf