Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	19783
Country	Japan

Received	2015-05-21 08:49
Peer-Review Started	2015-05-21 16:39
To Make the First Decision	2015-07-02 13:30
Return for Revision	2015-07-10 14:44
Revised	2015-07-15 17:57
Second Decision	2015-09-02 15:43
Accepted by Journal Editor-in-Chief	2015-09-02 22:43
Accepted by Executive Editor-in-Chief	2015-09-16 18:49
Articles in Press	2015-09-16 18:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-23 09:31
Publish the Manuscript Online	2015-11-12 18:51

ISSN	2150-5349 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Direct antiviral agent treatment of decompensated hepatitis C virus-induced liver cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Shogo Ohkoshi, Haruka Hirono and Satoshi Yamagiwa
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research (C) Japan Society for the Promotion of Science 25461012 for Shogo Ohkoshi
Corresponding Author	Shogo Ohkoshi, MD, PhD, Department of Internal Medicine, School of Life Dentistry at Niigata, the Nippon Dental University, 1-8 Hamaura-Cho, Chuo-ku, Niigata-city 951-8580, Japan. okoshi@ngt.ndu.ac.jp
Key Words	Hepatitis C virus; Decompensated liver cirrhosis; Prognosis; Direct antiviral agent; Comorbidity; Nucleic acid analogue
Core Tip	Decompensated liver cirrhosis (LC) due to hepatitis C virus (HCV) infection is a severe disease with poor prognosis. Because interferon-included regimens are contraindicated at this stage, liver transplantation has been the only way to cure the disease. However, recent development of direct antiviral agents (DAAs) is offering a hope for this difficult situation. Promising antiviral effects of DAAs for LC have been observed, suggesting they might be useful for treatment of decompensated HCV-LC. To explore this possibility, large case-control studies are needed.
Publish Date	2015-11-12 18:51
Citation	Ohkoshi S, Hirono H, Yamagiwa S. Direct antiviral agent treatment of decompensated hepatitis C virus-induced liver cirrhosis. World J Gastrointest Pharmacol Ther 2015; 6(4): 114-119
URL	http://www.wjgnet.com/2150-5349/full/v6/i4/114.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v6.i4.114

Full Article (PDF)	WJGPT-6-114.pdf
Full Article (Word)	WJGPT-6-114.doc
Manuscript File	19783-Review.docx
Answering Reviewers	19783-Answering reviewers.pdf
Audio Core Tip	19783-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19783-Conflict-of-interest statement.pdf
Copyright License Agreement	19783-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19783-Language certificate.doc
Peer-review Report	19783-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19783-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19783-Scientific misconduct check.pdf
Scientific Editor Work List	19783-Scientific editor work list.pdf