Publication Name	World Journal of Gastroenterology
Manuscript ID	19822
Country	Singapore

Received	2015-05-22 16:34
Peer-Review Started	2015-05-23 15:15
First Decision by Editorial Office Director
Return for Revision	2015-07-27 11:24
Revised	2015-09-10 17:34
Publication Fee Transferred
Second Decision by Editor	2015-10-12 09:06
Second Decision by Editor-in-Chief	2015-10-12 20:52
Final Decision by Editorial Office Director	2015-10-20 09:51
Articles in Press	2015-10-20 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-26 16:57
Publish the Manuscript Online	2015-12-09 17:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1
Manuscript Source	Unsolicited Manuscript
All Author List	Weiqi Tan, Seng-Gee Lim and Theresa MC Tan
Funding Agency and Grant Number	Funding Agency Grant Number Biomedical Research Council and Ministry of Education (Tier 1) to Tan TM
Corresponding Author	Theresa MC Tan, Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore S117597, Singapore. bchtant@nus.edu.sg
Key Words	MicroRNA-210; Hepatocellular carcinoma; Proliferation; Yes1
Core Tip	In this study, miR-210 is significantly up-regulated in hepatocellular carcinoma (HCC). Over-expression of miR-210 decreased cell proliferation and delayed cell cycle progression of HCC cells. The tyrosine kinase Yes1 is shown to be a target of miR-210 and is down-regulated in HCC. Knock-down of Yes1 by siRNA also significantly reduced cell proliferation. These results increase the understanding of the multiple roles of miR-210 in liver cancer growth and metastasis.
Publish Date	2015-12-09 17:57
Citation	Tan W, Lim SG, Tan TMC. Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1. World J Gastroenterol 2015; 21(46): 13030-13041
URL	http://www.wjgnet.com/1007-9327/full/v21/i46/13030.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i46.13030

Full Article (PDF)	WJG-21-13030.pdf
Full Article (Word)	WJG-21-13030.doc