Publication Name	World Journal of Stem Cells
Manuscript ID	19824
Country	Australia

Received	2015-05-22 14:24
Peer-Review Started	2015-05-23 17:41
To Make the First Decision	2015-07-27 15:46
Return for Revision	2015-08-04 10:01
Revised	2015-08-20 00:00
Second Decision	2015-11-02 14:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-11 17:51
Articles in Press	2015-11-11 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-03 15:31
Publish the Manuscript Online	2015-12-25 08:04

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Multipotent pancreas progenitors: Inconclusive but pivotal topic
Manuscript Source	Invited Manuscript
All Author List	Fang-Xu Jiang and Grant Morahan
Funding Agency and Grant Number	Funding Agency Grant Number Telethon Perth Child Health Research Foundation Diabetes Research Foundation of Western Australia University of Western Australia National Health and Medical Research Council Program 53000400
Corresponding Author	Fang-Xu Jiang, Associate Professor, Islet Cell Development Program, Harry Perkins Institute of Medical Research, 6 Verdun St, Nedlands, WA 6009, Australia. fang-xu.jiang@perkins.uwa.edu.au
Key Words	Multipotent pancreas progenitors; Regenera­tion; Self-renewal; Clonogenesis; Differentiation
Core Tip	Diabetes mellitus is a pandemic health problem that currently affects approximately 400 million people worldwide and its incidence is increasing by 2%-3% per year. At present, insulin deficiency in diabetes is treated by exogenous insulin given as either multiple daily injections or continuous subcutaneous infusion (pump), which is associated with acute, potentially life-threatening metabolic disturbances as well as chronic, vascular com-plications with significant morbidity and mortality. The ultimate solution would therefore be regenerative therapies by which lost β-cells in disease processes could be restored/replaced by surrogate insulin-secreting cells including those derived from multipotent pancreas progenitors.
Publish Date	2015-12-25 08:04
Citation	Jiang FX, Morahan G. Multipotent pancreas progenitors: Inconclusive but pivotal topic. World J Stem Cells 2015; 7(11): 1251-1261
URL	http://www.wjgnet.com/1948-0210/full/v7/i11/1251.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i11.1251

Full Article (PDF)	WJSC-7-1251.pdf
Full Article (Word)	WJSC-7-1251.doc
Manuscript File	19824-Review.docx
Answering Reviewers	19824-Answering reviewers.pdf
Audio Core Tip	19824-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19824-Conflict-of-interest statement.pdf
Copyright License Agreement	19824-Copyright assignment.pdf
Peer-review Report	19824-Peer-review(s).pdf
Scientific Misconduct Check	19824-Scientific misconduct check.pdf
Scientific Editor Work List	19824-Scientific editor work list.pdf