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Articles Published Processes
4/12/2016 1:04:00 PM | Browse: 1416 | Download: 1997
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Received |
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2015-05-24 12:33 |
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Peer-Review Started |
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2015-05-25 18:57 |
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To Make the First Decision |
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2015-08-26 13:55 |
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Return for Revision |
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2015-09-29 16:05 |
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Revised |
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2015-11-10 00:00 |
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Second Decision |
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2015-12-03 08:05 |
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Accepted by Journal Editor-in-Chief |
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2015-12-03 09:25 |
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Accepted by Executive Editor-in-Chief |
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2015-12-14 16:08 |
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Articles in Press |
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2015-12-14 16:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-18 08:21 |
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Typeset the Manuscript |
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2016-03-24 11:30 |
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Publish the Manuscript Online |
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2016-04-03 18:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying-Lin Niu, Ya-Jun Li, Jing-Bo Wang, Yuan-Yuan Lu, Zhen-Xiong Liu, Shan-Shan Feng, Jian-Guo Hu and Hui-Hong Zhai |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81072040 |
| Specialized Research Fund for the Doctoral Program of Ningxia Medical University |
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| Corresponding Author |
Hui-Hong Zhai, MD, PhD, Department of Digestive Diseases, General Hospital of Ningxia Medical University, 804 Shengli Street, Xingqing Area, Yinchuan 750004, Ningxia Hui Autonomous Region, China. zhaihuihong@263.net |
| Key Words |
Calcyclin binding protein/Siah-1 interacting protein; Gastric cancer; Cell cycle; P27kip1; Ubiquitin |
| Core Tip |
Calcyclin binding protein/Siah-1 interacting protein (CacyBP/SIP) is a component of the ubi-quitination pathway. Our study showed that defects in G1 arrest led to an increase in embryonic fibroblast growth rate in SIP-/- mice, and CacyBP/SIP could promote G1/S transition of pancreatic cancer cells and regulate the glucose limitation-induced p27 degradation. In gastric cancer (gc) tissue, CacyBP/SIP was identified to be expressed in the nuclei and could translocate into the nucleus after induction with gastrin and promote cell proliferation; however, the mechanism remains unclear. In the present investigation, the mechanism of CacyBP/SIP nuclear translocation in promoting the growth of gc cells was studied. |
| Publish Date |
2016-04-03 18:51 |
| Citation |
Niu YL, Li YJ, Wang JB, Lu YY, Liu ZX, Feng SS, Hu JG, Zhai HH. CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells. World J Gastroenterol 2016; 22(15): 3992-4001 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i15/3992.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i15.3992 |
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