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Articles Published Processes
3/23/2016 4:26:00 PM | Browse: 812 | Download: 1392
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Received |
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2015-05-25 08:41 |
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Peer-Review Started |
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2015-05-25 09:09 |
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To Make the First Decision |
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2015-06-25 17:45 |
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Return for Revision |
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2015-06-26 20:14 |
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Revised |
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2015-08-09 21:25 |
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Second Decision |
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2015-10-14 09:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-10-26 17:48 |
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Articles in Press |
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2015-10-26 17:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-02-16 22:01 |
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Typeset the Manuscript |
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2016-03-09 15:04 |
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Publish the Manuscript Online |
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2016-03-23 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Feng-Yan Yu, Shao-Gang Huang, Hai-Yan Zhang, Hua Ye, Hong-Gang Chi, Ying Zou, Ru-Xi Lv and Xue-Bao Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Guangdong Province of China |
S2012040006557 |
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| Corresponding Author |
Shao-Gang Huang, PhD, Professor, Director, University City Branch Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, Inner Ring Road, Panyu District, Guangzhou 510006, Guangdong Province, China. huangshaogang@126.com
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| Key Words |
Stomach type diarrhea; Diarrhea-predominant irritable bowel syndrome; Ulcerative colitis in remission; 5-Hydroxytryptophan |
| Core Tip |
Irritable bowel syndrome (IBS) is among the most common functional gastrointestinal disorders, but its pathogenesis is not understood. Ulcerative colitis (UC) is a chronic non-specific inflammatory gastrointestinal disease. Visceral hypersensitivity is the most well-known cause of abdominal pain related to diarrhea-predominant IBS (IBS-D) and UC. The 5-hydroxytryptophan (5-HT) signaling pathway is important for both sensory signal transduction in gastrointestinal motility and the development of visceral hypersensitivity. This study examined visceral sensitivity differences in the colonic mucosa between IBS-D and UC remission groups with respect to the 5-HT signaling pathway. We offer a new theoretical basis for Chinese medical treatment for the two types of common intestinal diseases related to 5-HT signaling pathways. These data will also provide new insights into future methods for the application of traditional Chinese medicine.
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| Publish Date |
2016-03-23 16:22 |
| Citation |
Yu FY, Huang SG, Zhang HY, Ye H, Chi HG, Zou Y, Lv RX, Zheng XB. Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. World J Gastroenterol 2016; 22(12): 3451-3459 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i12/3451.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i12.3451 |
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