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Articles Published Processes
12/9/2015 5:57:00 PM | Browse: 959 | Download: 1712
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Received |
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2015-05-28 17:52 |
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Peer-Review Started |
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2015-05-29 08:24 |
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To Make the First Decision |
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2015-06-25 17:49 |
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Return for Revision |
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2015-07-05 16:03 |
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Revised |
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2015-08-09 21:02 |
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Second Decision |
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2015-10-10 18:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-10-13 18:26 |
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Articles in Press |
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2015-10-13 18:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-10-28 04:24 |
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Typeset the Manuscript |
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2015-11-25 09:12 |
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Publish the Manuscript Online |
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2015-12-09 17:57 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Chang Lei, Ling-Ling Yang, Wen Li, Pan Luo and Pei-Fen Zheng |
| Funding Agency and Grant Number |
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| Corresponding Author |
Pei-Fen Zheng, Chief Physician, Department of Gastroenterology, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, Zhejiang Province, China. ycleihust@sina.com |
| Key Words |
Acute liver failure; Sphingosine kinase 1; High-mobility group box 1; Cytoplasmic translocation; Inflammatory cytokine |
| Core Tip |
Recent studies demonstrated that sphingosine kinase 1 (Sphk1) plays a critical role in sepsis-induced inflammatory responses and high-mobility group box 1 (HMGB1) cytoplasmic translocation has an important role in acute liver failure (ALF). The finding that SphK1 is able to mediate the secretion of proinflammatory mediators prompted us to investigate its role in systemic inflammatory response caused by ALF. In the present study, we demonstrated that SphK1 was critical in D-galactosamine/lipopolysaccharide-induced ALF in mice and that inhibition of SphK1 ameliorated ALF by reducing HMGB1 cytoplasmic translocation in liver cells in this animal model. Our findings suggest that inhibition of SphK1 might be a potential therapeutic strategy for ALF. |
| Publish Date |
2015-12-09 17:57 |
| Citation |
Lei YC, Yang LL, Li W, Luo P, Zheng PF. Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. World J Gastroenterol 2015; 21(46): 13055-13063 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i46/13055.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i46.13055 |
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