Publication Name	World Journal of Gastroenterology
Manuscript ID	19890
Country	China

Received	2015-05-25 08:50
Peer-Review Started	2015-05-25 09:16
To Make the First Decision	2015-06-25 17:50
Return for Revision	2015-07-10 08:52
Revised	2015-09-05 20:55
Second Decision	2015-11-11 16:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-30 19:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-17 12:01
Typeset the Manuscript	2016-01-17 18:31
Publish the Manuscript Online	2016-01-31 11:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effects of endoplasmic reticulum stress on the expression of inflammatory cytokines in patients with ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Nan Li, Xue-Ming Wang, Li-Jun Jiang, Meng Zhang, Na Li, Zhen-Zhen Wei, Nan Zheng and Ya-Jiao Zhao
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Natural Scientific Research Foundation 7132175
Corresponding Author	Nan Li, Dean, Chief Physician, Doctoral Supervisor, Department of Gastrology, PLA 309 Hospital, No 17 Heishanhujia, Haidian District, Beijing 100091, China. linanforty@163.com
Key Words	Ulcerative colitis; Endoplasmic reticulum stress; X-box binding protein 1 splicing
Core Tip	Endoplasmic reticulum stress (ERS) can repair stress-induced cell damage and restore normal cell function by the inositol-requiring enzyme 1/X-box binding protein 1 splicing (IRE1/XBP1) signalling pathway. However, the link to ulcerative colitis (UC) remains unclear. In the present study, we report that T lymphocytes respond to ERS by activating the IRE1/XBP1 signalling pathway, upregulating the expression of inflammatory cytokines, and increasing the occurrence of inflammation. In addition, mononuclear cells in the peripheral blood of patients with UC were more sensitive to ERS than normal subjects.
Publish Date	2016-01-31 11:48
Citation	Li N, Wang XM, Jiang LJ, Zhang M, Li N, Wei ZZ, Zheng N, Zhao YJ. Effects of endoplasmic reticulum stress on the expression of inflammatory cytokines in patients with ulcerative colitis. World J Gastroenterol 2016; 22(7): 2357-2365
URL	http://www.wjgnet.com/1007-9327/full/v22/i7/2357.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i7.2357

Full Article (PDF)	WJG-22-2357.pdf
Full Article (Word)	WJG-22-2357.doc
Manuscript File	19890-Review.doc
Answering Reviewers	19890-Answering reviewers.pdf
Audio Core Tip	19890-Audio core tip.mp3
Biostatistics Review Certificate	19890-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19890-Conflict-of-interest statement.pdf
Copyright License Agreement	19890-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19890-Language certificate.pdf
Peer-review Report	19890-Peer-review(s).pdf
Scientific Misconduct Check	19890-Scientific misconduct check.pdf
Scientific Editor Work List	19890-Scientific editor work list.pdf