Publication Name	World Journal of Virology
Manuscript ID	19905
Country	Thailand

Received	2015-05-26 10:20
Peer-Review Started	2015-05-26 19:22
First Decision by Editorial Office Director
Return for Revision	2015-08-01 18:37
Revised	2015-08-06 15:40
Publication Fee Transferred
Second Decision by Editor	2015-09-10 08:19
Second Decision by Editor-in-Chief	2015-09-11 10:32
Final Decision by Editorial Office Director	2015-09-18 14:09
Articles in Press	2015-09-18 14:09
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 09:51
Publish the Manuscript Online	2015-11-12 17:09

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Virology
Manuscript Type	Review
Article Title	Hepatitis E virus infection: Epidemiology and treatment implications
Manuscript Source	Invited Manuscript
All Author List	Ga Young Lee, Kittiyod Poovorawan, Duangnapa Intharasongkroh, Pattaratida Sa-nguanmoo, Sompong Vongpunsawad, Chintana Chirathaworn and Yong Poovorawan
Funding Agency and Grant Number	Funding Agency Grant Number National Research University Project, Office of Higher Education Commission WCU001-HR-57 National Research University Project, Office of Higher Education Commission WCU007-HR-57 National Research University Project, Office of Higher Education Commission WCU-58-006-HR National Research Council of Thailand National Science and Technology Development Agency, Chulalongkorn University Centenary Academic Development Project CU56-HR01 Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University RES560530093 Outstanding Professor of Thailand Research Fund DPG5480002 Rachadapisek Sompote Fund of Chulalongkorn University for Postdoctoral Fellowship to Pattaratida Sa-nguanmoo
Corresponding Author	Yong Poovorawan, MD, Professor, Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama Ⅳ Rd, Bangkok 10330, Thailand. yong.p@chula.ac.th
Key Words	Treatments; Blood donors; Adverse effects; Vaccination; Pegylated-interferon; Ribavirin; Hepatitis E
Core Tip	Hepatitis E virus (HEV) infection affects indivi-duals in both industrialized and developing countries and can cause acute and chronic hepatitis E. HEV genotypes 1 and 2 are primarily found in developing countries due to waterborne transmission, while the zoonotic potential of genotypes 3 and 4 affects mostly industrialized countries. An awareness of HEV transmission through blood donation, especially in the immunocompromised and solid organ transplant patients, merits an effective anti-viral therapy. The current treatment for HEV infection involving ribavirin and pegylated interferon-α therapy has shown limited efficacy. Although not widely used, an HEV vaccine is available for immunization in China.
Publish Date	2015-11-12 17:09
Citation	Lee GY, Poovorawan K, Intharasongkroh D, Sa-nguanmoo P, Vongpunsawad S, Chirathaworn C, Poovorawan Y. Hepatitis E virus infection: Epidemiology and treatment implications. World J Virol 2015; 4(4): 343-355
URL	http://www.wjgnet.com/2220-3249/full/v4/i4/343.htm
DOI	http://dx.doi.org/10.5501/wjv.v4.i4.343

Full Article (PDF)	WJV-4-343.pdf
Full Article (Word)	WJV-4-343.doc
Manuscript File	19905-Review.docx
Answering Reviewers	19905-Answering reviewers.pdf
Audio Core Tip	19905-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19905-Conflict-of-interest statement.pdf
Copyright License Agreement	19905-Copyright assignment.pdf
Peer-review Report	19905-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19905-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19905-Scientific misconduct check.pdf
Scientific Editor Work List	19905-Scientific editor work list.pdf